Fc R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
نویسندگان
چکیده
1Herman B Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), Riley Hospital for Children, Indiana University School of Medicine, Indianapolis; 2Department of Biology and 3Division of Biological Engineering, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge; 4Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA; 5Division of Cell Biology, Hospital for Sick Children, Toronto, ON; and Departments of 6Medicine (Nephrology) and 7Microbiology/Immunology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis
منابع مشابه
Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.
The phagocyte NADPH oxidase generates superoxide for microbial killing, and includes a membrane-bound flavocytochrome b(558) and cytosolic p67(phox), p47(phox), and p40(phox) subunits that undergo membrane translocation upon cellular activation. The function of p40(phox), which binds p67(phox) in resting cells, is incompletely understood. Recent studies showed that phagocytosis-induced superoxi...
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