Safety of linezolid in patients with baseline thrombocytopenia.

نویسندگان

  • Shellee A Grim
  • Lisa Rene
  • Sandeep Gupta
  • Nina M Clark
چکیده

1. Chow KM, Hui AC, Szeto CC. Neurotoxicity induced by b-lactam antibiotics: from bench to bedside. Eur J Clin Microbiol Infect Dis 2005; 24: 649–53. 2. Yahav D, Paul M, Fraser A et al. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet infect Dis 2007; 7: 338–48. 3. Dixit S, Kurle P, Buyan-Dent L et al. Status epilepticus associated with cefepime. Neurology 2000; 54: 2153–5. 4. Lam S, Gomolin IH. Cefepime neurotoxicity: case report pharmacokinetic considerations literature review. Pharmacotherapy 2006; 26: 1169–74. 5. Chow KM, Szeto CC, Hui AC et al. Mechanisms of antibiotic neurotoxicity in renal failure. Int J Antimicrob Agents 2004; 23: 213–7. 6. Malone RS, Fish DN, Abraham E et al. Pharmacokinetics of cefepime during continuous renal replacement therapy in critically ill patients. Antimicrob Agents Chemother 2001; 45: 3148–55. 7. Allaouchiche B, Breilh D, Jaumain H et al. Pharmacokinetics of cefepime during continuous venovenous hemodiafiltration. Antimicrob Agents Chemother 1997; 41: 2424–7. 8. Isla A, Gascon AR, Maynar J et al. Cefepime and continuous renal replacement therapy (CRRT): in vitro permeability of two CRRT membranes and pharmacokinetics in four critically ill patients. Clin Ther 2005; 27: 599–608.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Efficacy of linezolid on gram-positive bacterial infection in elderly patients and the risk factors associated with thrombocytopenia

UNLABELLED Objective : Linezolid is active against drug-resistant gram-positive bacteria. However, the efficacy and safety of linezolid in the treatment of the elderly have not been well characterized. The purpose of this study was to evaluate the efficacy of linezolid in the treatment of the elderly with gram-positive bacterial infection and to investigate the risk factors associated with the ...

متن کامل

Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid.

Hematological disturbances that develop during linezolid treatment are a major concern when linezolid is administered for prolonged periods of time. The aim of this study was to evaluate the influences of pyridoxine, rifampin, and renal function on hematological adverse events. From January 2002 to April 2006, 52 patients received a long-term course of linezolid. Blood cell counts were monitore...

متن کامل

A comparative evaluation of adverse platelet outcomes among Veterans' Affairs patients receiving linezolid or vancomycin.

OBJECTIVES The primary objectives were to compare the incidences of severe thrombocytopenia, critical thrombocytopenia and a relative decline in platelets from baseline (≥50% decline) between patients receiving linezolid and those receiving vancomycin. The secondary objective was to assess the relationship between vancomycin trough concentration and adverse platelet outcomes. METHODS A matche...

متن کامل

In the Literature Can We Prevent Linezolid - Associated Anemia and Thrombocytopenia ?

The most frequently encountered adverse effects of linezolid therapy are anemia and thrombocytopenia, both of which are observed mostly in individuals receiving the drug for 12 weeks, and both of which are generally reversible after discontinuation of treatment. This effect appears to be the result of bone marrow suppression, possibly as a consequence of inhibition of mitochondrial protein synt...

متن کامل

Study on the linezolid prescription according to the approval of indication in a University Hospital

Indications for linezolid use are nosocomial or community-acquired pneumonia and skin infections or soft tissue infection caused by gram-positive microorganisms, but new recommendations may emerge. It is important to balance benefits with risks because severe adverse events have been described in patients taking linezolid treatment. Accordingly, we evaluated the suitability of linezolid prescri...

متن کامل

A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis.

Linezolid is used to treat patients with multidrug-resistant (MDR)/extensively drug-resistant (XDR)-tuberculosis (TB) cases, although clinical data on its safety, tolerability and efficacy are lacking. We performed a retrospective, nonrandomised, unblinded observational study evaluating the safety and tolerability of linezolid at 600 mg q.d. or b.i.d. in MDR/XDR-TB treatment in four European co...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of antimicrobial chemotherapy

دوره 62 4  شماره 

صفحات  -

تاریخ انتشار 2008