Prevalence of antibodies to human T-lymphotropic virus types I and II among Saudi Arabian blood donors.
نویسنده
چکیده
In 1980 and 1982, Gallo et al. described the isolation of human T-cell lymphotropic virus type I (HTLV-I) and type II (HTLV-II). In the majority of cases, infection with these viruses does not cause diseases. However, HTLV-I infection has been etiologically associated with neoplastic diseases and a variety of demyelinating neurologic disorders. The association of HTLV-II with leukemia pathogenesis is not well established, however, some cases of neurological disease have been reported. HTLV-I infection may be transmitted via blood transfusion. Cellular blood components transmit the virus with 20%-63% efficiency. Among recipients of HTLV-Icontaminated blood components, the mean interval from infection to antibody seroconversion is 40 days (range, 2090 days). The transmission of HTLV-II via blood transfusion has been documented. HTLV-I is now recognized to occur worldwide, although it is characteristically endemic in Japan, the Caribbean, Southern Italy, New Guinea, Africa, and the Seychelles, as well as in several countries in the Middle East. In the present study, we took sera from volunteer Saudi blood donors and hemodialysis patients over a three-year period to determine the prevalence of HTLV-I/II among Saudi blood donors, and to examine the cost effectiveness of HTLV screening in Saudi blood banks.
منابع مشابه
Evaluating the frequency of HTLV-Ι/Π infection among blood donors, major thalassemic patients and individuals infected with hepatitis B and C viruses in Isfahan, Iran
Background: The human T-cell lymphotropic virus type I is the first retrovirus idenfied in humans. The virus has been associated with adult T-cell leukemia/lymphoma, human T-lymphotropic virus type I, myelopathy/tropical spasc paraparesis, uveis, arthris, pulmonary lymphocyc alveolis, keratoconjuncvis sicca, and infecous dermas. Human T-lymphotropic virus type Iis endemic in Japan...
متن کاملEvaluating the Frequency of Human T-Lymphotropic Virus Type 1 Infection in Iranian Population
Background: Human T-cell lymphotropic viruses 1 (HTLV1) is endemic in specific regions. We aimed to determine the prevalence of HTLV I infection among blood donors in southeast Iran. Methods: This cross-sectional study was conducted between April 2005 and March 2015. Sera were collected from blood donors and were tested for the presence of HTLV1 specific antibody using ELISA. Reactive sample...
متن کاملPrevalence of HBV, HCV, HIV-1, 2 and HTLV-I/II infections among blood donors in a teaching hospital in the Central region of Saudi Arabia.
OBJECTIVE Several infectious diseases are transmissible by blood transfusion, especially viral infections. The most common blood-transmitted viruses are hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). These viruses cause fatal, chronic and life-threatening disorders. The prevalence of these viruses varies by nationality and geography. The purpose of this...
متن کاملPrevalence of Seropositivity for Human T lymphocytes Virus in Patients with Hereditary Bleeding Diseases in Population of West Azerbaijan
Background and Aims: Human T-lymphotropic virus (HTLV) is a human retrovirus which has been known to cause adult T-cell leukemia/lymphoma and some other inflammatory disorders. Patients with hereditary bleeding diseases are at high risk for these viruses. In this study, we evaluated serological HTLV-I/II infection among these patients in west Azerbaijan of Iran. Material and Methods: We stud...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of Saudi medicine
دوره 20 2 شماره
صفحات -
تاریخ انتشار 2000