Letrozole as an Ovulation Inducing Drug in Anovulatory Patients
نویسنده
چکیده
Introduction nfertility is defined as the inability of a couple to achieve conception after one year of regular unprotected coitus'. Sterility implies an intrinsic inability to achieve pregnancy, whereas infertility implies a disease in the ability to conceive and is synonymous with subfertility. Approximately 90% of couples with unprotected intercourse will conceive within 1 year and sterility affects 12% of Couples. Primary sub-fertility is an absolute state of inability to conceive whereas secondary sub-fertility is the same state developing after an initial phase of fertility.
منابع مشابه
Letrozole versus Clomiphene Citrate in Patients with Anovulatory Infertility
Objective: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. Design: Open, prospective, randomized, parallel group, multicentric, comparative trial. Setting: Outpatient clinics of infertility centers in India. Patient(s): Fifty-five patients with anovulatory infertility were recruited. Twenty-seven patients (59 cycles) were given let...
متن کاملO-29: Pregnancies Following the Use of SequentialTreatment of Metformin and IncrementalDoses of Letrozole in Clomiphen-ResistantWomen with Polycystic Ovary Syndrome
Background: Clomiphen citrate (CC) is the first line therapy for women with infertility and poly cystic ovary syndrome( PCOS).However, 20-25% of women are resistant to CC and do not ovulate. The Background of this study is to evaluate the efficacy of sequential treatment of metformin and incremental doses of letrozole in induction of ovulation in cases of clomiphen citrateresistant (CC- R) PCOS...
متن کاملLetrozole or clomiphene citrate as first line for anovulatory infertility: a debate
Clomiphene citrate has been traditionally used as the drug of choice in treating women with anovulatory infertility. In the last decade letrozole, an aromatase inhibitor has emerged as alternative ovulation induction agent. Literature confirms that letrozole has a definitive role in anovulatory women who have not responded to the clomiphene therapy. However its role as an alternative to clomiph...
متن کاملComparison of acupuncture pretreatment followed by letrozole versus letrozole alone on live birth in anovulatory infertile women with polycystic ovary syndrome: a study protocol for a randomised controlled trial
INTRODUCTION The high prevalence of insulin resistance in women with polycystic ovary syndrome (PCOS) is considered to be one of the major pathophysiological changes in PCOS that leads to anovulatory infertility. We hypothesise that electroacupuncture pretreatment improves insulin sensitivity and leads to a higher ovulation rate and greater chances of live birth after the induction of ovulation...
متن کاملLetrozole versus Clomiphene Citrate for Induction of Ovulation in Patients with Polycystic Ovarian Syndrome Undergoing Intrauterine Insemination
BACKGROUND Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women in the reproductive age group, and is one of the most common causes of hyperandrogenic anovulatory infertility. The aromatase inhibitor, letrozole, has been used for induction of ovulation. The purpose of this study was to compare the effects of letrozole and clomiphene citrate in induction of...
متن کامل