A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia Short title: GFI1 allele in AML
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چکیده
Cyrus Khandanpour, Christian Thiede, Peter J.M. Valk, Ehssan Sharif-Askari, Holger Nückel, Dietmar Lohmann, Bernhard Horsthemke, Winfried Siffert, Andreas Neubauer, Karl-Heinz Grzeschik, Clara D. Bloomfield, Guido Marcucci, Kati Maharry, Marilyn L. Slovak, Bert A. van der Reijden, Joop H. Jansen, Hans K. Schackert, Khashayar Afshar, Susanne Schnittger, Justine K. Peeters, Frank Kroschinsky, Gerhard Ehninger, Bob Lowenberg, Ulrich Dührsen, and Tarik Möröy *
منابع مشابه
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.
The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation. In the mouse, Gfi1 deficiency causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome. We report here that a variant allele of GFI1 (GFI1(36N)) is associated with acute myeloid leukemia (AML) in white subjects with an odds ratio of 1.6 ...
متن کاملThe human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GFI1) is present in 3%-7% of whites and increases the risk for acute myeloid leukemia (AML) by 60%. We show here that GFI136N, in contrast to GFI136S, lacks the ability to bind to the Gfi1 target gene that encodes the leukemia-associated transcription factor Hoxa9 and fails to initiate histone modi...
متن کاملMYELOID NEOPLASIA A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
Cyrus Khandanpour,1-3 Christian Thiede,4 Peter J. M. Valk,5 Ehssan Sharif-Askari,1 Holger Nückel,3 Dietmar Lohmann,6 Bernhard Horsthemke,6 Winfried Siffert,7 Andreas Neubauer,8 Karl-Heinz Grzeschik,9 Clara D. Bloomfield,10 Guido Marcucci,10 Kati Maharry,10,11 Marilyn L. Slovak,12 Bert A. van der Reijden,13 Joop H. Jansen,13 Hans K. Schackert,14 Khashayar Afshar,1 Susanne Schnittger,15 Justine K...
متن کاملTranscription Factor GFI1B in Health and Disease
Many human diseases arise through dysregulation of genes that control key cell fate pathways. Transcription factors (TFs) are major cell fate regulators frequently involved in cancer, particularly in leukemia. The GFI1B gene, coding a TF, was identified by sequence homology with the oncogene growth factor independence 1 (GFI1). Both GFI1 and GFI1B have six C-terminal C2H2 zinc fingers and an N-...
متن کاملThe transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.
The transcription factor growth factor independence 1 (Gfi1) and the growth factor granulocyte colony-stimulating factor (G-CSF) are individually essential for neutrophil differentiation from myeloid progenitors. Here, we provide evidence that the functions of Gfi1 and G-CSF are linked in the regulation of granulopoiesis. We report that Gfi1 promotes the expression of Ras guanine nucleotide rel...
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تاریخ انتشار 2010