Patrick Cramer Anton Meinhart , Tobias Silberzahn and Phosphatase Factor Ssu 72 Is a Potential Tyrosine
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Cramer Anton Meinhart , Jascha Blobel and Patrick α General Transcription Factor E / IIE An Extended Winged Helix Domain in
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Structure and mechanism of RNA polymerase II CTD phosphatases.
Recycling of RNA polymerase II (Pol II) after transcription requires dephosphorylation of the polymerase C-terminal domain (CTD) by the phosphatase Fcp1. We report the X-ray structure of the small CTD phosphatase Scp1, which is homologous to the Fcp1 catalytic domain. The structure shows a core fold and an active center similar to those of phosphotransferases and phosphohydrolases that solely s...
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The C-terminal domain (CTD) of RNA polymerase II (Pol II) integrates nuclear events by binding proteins involved in mRNA biogenesis. CTD-binding proteins recognize a specific CTD phosphorylation pattern, which changes during the transcription cycle, due to the action of CTD-modifying enzymes. Structural and functional studies of CTD-binding and -modifying proteins now reveal some of the mechani...
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Bernd Terhalle, Tobias Richter, Kody J. H. Law, Dennis Göries, Patrick Rose, Tristram J. Alexander, Panayotis G. Kevrekidis, Anton S. Desyatnikov, Wieslaw Krolikowski, Friedemann Kaiser, Cornelia Denz, and Yuri S. Kivshar Nonlinear Physics Center and Laser Physics Center, Research School of Physics and Engineering, The Australian National University, Canberra ACT 0200, Australia Institut für An...
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