Effects on Pharmacokinetics of Tacrolimus in Liver Transplant Patients

For most drugs, initial dosage for different individuals is associated with many factors, such as weight and age. If drug blood concentrations can be measured, the dosage of the drug may be adjusted to the blood value to get an acceptable range. With regards to immunosuppressive drugs, like tacrolimus, dose that is too low could cause organ rejection, and a dose that is too high could cause toxicity [2,3]. Achieving a steady target blood concentration is critical to avoid rejection and adverse drug effects [4].