Multidimensional regulation of lipoprotein lipase: impact on biochemical and cardiovascular phenotypes.
نویسنده
چکیده
منابع مشابه
Analysis of the association Hind III Polymorphism of Lipoprotein Lipase gene on the risk of coronary artery disease
Background: Coronary artery disease (CAD) is one of the leading causes of death and disability around the world. Interaction between genetic and environmental factors determines susceptibility of an individual to develop coronary artery disease . Lipoprotein lipase (LPL) play an important role in the metabolism of HDL-C ( High Density Lipoprotein Cholesterol ), LDL-C (Low Density Lipoprotein Ch...
متن کاملبررسی عوامل خطرزای بیماری‌های قلبی و عروقی بر حسب فنوتیپ‌های سندرم تخمدان پلی‌کیستیک در دختران 18-14 ساله دبیرستانی شهر شیراز 1389
Introduction: In patients with polycystic ovary syndrome hyperinsulinaemia, insulin resistance, dyslipidemia and hyperglycemia may represent an increased risk for coronary cardiovascular disease .This study aimed to investigate risk factors for cardiovascular disease based on polycystic ovary syndrome phenotypes in Shiraz. Methods: This Cross-sectional study was performed on 3200 students aged...
متن کاملTwo different mechanisms are involved in nutritional regulation of lipoprotein lipase in guinea-pig adipose tissue.
Lipoprotein lipase activity in adipose tissue responds rapidly to changes in the physiological state. To study what mechanisms are involved in the regulation, guinea pigs were fasted and the decrease in adipose-tissue lipoprotein lipase activity was compared with the decreases in mRNA and lipase synthesis. The mRNA pattern (three species) did not change. There was a close parallelism between th...
متن کاملPossible role of lipoprotein lipase in the regulation of endogenous triacylglycerols in the rat heart.
1. Adrenaline has a biphasic effect on intracellular lipoprotein lipase activity and on endogenous triacylglycerol content in heparin-perfused heart. 2. A high concentration of adrenaline (1 microM in the perfusion buffer) activated endogenous lipoprotein lipase activity and, at the same time, decreased intracellular triacylglycerol stores. 3. In contrast, a low concentration (0.005 microM-adre...
متن کاملA common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia.
BACKGROUND Recently, a mutation in the lipoprotein lipase (LPL) gene (N291S) has been reported in 2% to 5% of individuals in western populations and is associated with increased triglyceride (TG) and reduced HDL cholesterol (HDLC) concentrations. METHODS AND RESULTS Here we report a significant alteration in biochemical and clinical phenotype in subjects with familial hypercholesterolemia (FH...
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ورودعنوان ژورنال:
- Journal of lipid research
دوره 57 9 شماره
صفحات -
تاریخ انتشار 2016