Restoration of Susceptibility of Intracellular Methicillin-Resistant Staphylococcus aureus to -Lactams: Comparison of Strains, Cells, and Antibiotics †
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چکیده
Restoration of Susceptibility of Intracellular Methicillin-Resistant Staphylococcus aureus to -Lactams: Comparison of Strains, Cells, and Antibiotics † Sandrine Lemaire, Aurélie Olivier, Françoise Van Bambeke, Paul M. Tulkens,* Peter C. Appelbaum, and Youri Glupczynski Unité de Pharmacologie Cellulaire et Moléculaire, Université Catholique de Louvain, Brussels, Belgium; Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania; and Laboratoire de Microbiologie, Cliniques Universitaires UCL de Mont-Godinne, Yvoir, Belgium
منابع مشابه
Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
Staphylococcus aureus invades eukaryotic cells. When methicillin-resistant S. aureus (MRSA) ATCC 33591 is phagocytized by human THP-1 macrophages, complete restoration of susceptibility to cloxacillin and meropenem is shown and the strain becomes indistinguishable from MSSA ATCC 25923 due to the acid pH prevailing in phagolysosomes (S. Lemaire et al., Antimicrob. Agents Chemother. 51:1627-1632,...
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