Molecular replacements
نویسندگان
چکیده
منابع مشابه
SwissBioisostere: a database of molecular replacements for ligand design
The SwissBioisostere database (http://www.swissbioisostere.ch) contains information on molecular replacements and their performance in biochemical assays. It is meant to provide researchers in drug discovery projects with ideas for bioisosteric modifications of their current lead molecule, as well as to give interested scientists access to the details on particular molecular replacements. As of...
متن کاملInvestigation of Wear Behavior of Biopolymers for Total Knee Replacements Through Invitro Experimentation
The average life span of knee prosthesis used in Total Knee Replacement (TKR) is approximately 10 to 15 years. Literature indicates that the reasons for implant failures include wear, infection, instability, and stiffness. However, the majority of failures are due to wear and tear of the prosthesis. The most common biopolymer used in TKR is Ultra High Molecular Weight Polyethylene (UHMWPE). Pr...
متن کاملDistribution of the strength of selection against amino acid replacements in human proteins.
The impact of an amino acid replacement on the organism's fitness can vary from lethal to selectively neutral and even, in rare cases, beneficial. Substantial data are available on either pathogenic or acceptable replacements. However, the whole distribution of coefficients of selection against individual replacements is not known for any organism. To ascertain this distribution for human prote...
متن کاملThe structural basis of molecular adaptation.
The study of molecular adaptation has long been fraught with difficulties, not the least of which is identifying out of hundreds of amino acid replacements those few directly responsible for major adaptations. Six studies are used to illustrate how phylogenies, site-directed mutagenesis, and a knowledge of protein structure combine to provide much deeper insights into the adaptive process than ...
متن کاملSignificantly different patterns of amino acid replacement after gene duplication as compared to after speciation.
We have performed a large-scale analysis of amino acid sequence evolution after gene duplication by comparing evolution after gene duplication with evolution after speciation in over 1,800 phylogenetic trees constructed from manually curated alignments of protein domains downloaded from the PFAM database. The site-specific rate of evolution is significantly altered by gene duplication. A signif...
متن کاملTemporal and topological clustering of diverged residues among enterobacterial dihydrofolate reductases.
The complete nucleotide and encoded amino acid sequences were determined for the dihydrofolate reductase (DHFR) from the bacteria Enterobacter aerogenes and Citrobacter freundii. These were compared with the closely related Escherichia coli DHFR sequence. The ancestral DHFR sequence common to these three species was reconstructed. Since that ancestor there have been seven, nine, and one amino a...
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