Which Dendrimer to Attain the Desired Properties? Focus on Phosphorhydrazone Dendrimers.
نویسندگان
چکیده
Among the six Critical Nanoscale Design Parameters (CNDPs) proposed by Prof. Donald A. Tomalia, this review illustrates the influence of the sixth one, which concerns the elemental composition, on the properties of dendrimers. After a large introduction that summarizes different types of dendrimers that have been compared with PolyAMidoAMine (PAMAM) dendrimers, this review will focus on the properties of positively and negatively charged phosphorhydrazone (PPH) dendrimers, especially in the field of biology, compared with other types of dendrimers, in particular PAMAM dendrimers, as well as polypropyleneimine (PPI), carbosilane, and p-Lysine dendrimers.
منابع مشابه
An azabisphosphonate-capped poly(phosphorhydrazone) dendrimer for the treatment of endotoxin-induced uveitis.
Over the last decade, different types of dendrimers have shown anti-inflammatory properties in their own right. In particular, we have shown that poly(phosphorhydrazone) (PPH) dendrimers are able to foster an efficient anti-inflammatory response in human monocytes and can resolve the main physiopathological features of chronic arthritis in mice at 1 mg/kg. Here we afford new insights into the t...
متن کاملPeptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review.
Dendrimers comprise a category of branched materials with diverse functions that can be constructed with defined architectural and chemical structures. When decorated with bioactive ligands made of peptides and saccharides through peripheral chemical groups, dendrimer conjugates are turned into nanomaterials possessing attractive binding properties with the cognate receptors. At the cellular le...
متن کاملDiffusion and trapping in dendrimer structures
We investigate diffusion on models of large molecules with dendrimer structure. The models we use are topological Cayley trees. We focus on diffusion properties, such as the excursion distance, the mean square displacement of the diffusing particles, and the area probed, as given by the random walk parameter SN , the number of the distinct sites visited. Finally we look at the trapping kinetics...
متن کاملDendrimer: Globular Nanostructured Materials for Drug Delivery
Nanotechnology is an emerging research field that helps in reviving the structural design, synthesis and fabrication at the molecular magnitude. There are approximately 130 nanopharmaceutical products in development including~nanoparticles, nanocrystals, dendrimers, liposomes and micelles. The increase in the selectivity and stability of therapeutic agents can be achieved with the help of Nanop...
متن کاملDendrimers in Cancer Treatment and Diagnosis
Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous and monodisperse structure consisting of tree-like arms or branches. Over the past two decades since the term ‘‘dendrimer’’ was formally defined, research interest in these molecules has gradually evolved from a primary focus on overcoming purely synthetic challenges to include aesthetic and theoretical persp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 23 3 شماره
صفحات -
تاریخ انتشار 2018