A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines
نویسندگان
چکیده
The Framingham Heart Study is a well known longitudinal cohort study. In recent years, the community-based Framingham Heart Study has embarked on genome-wide association studies. In this paper, we present a Framingham Heart Study genome-wide analysis for fasting triglycerides trait in the Genetic Analysis Workshop16 Problem 2 using multivariate adaptive splines for the analysis of longitudinal data (MASAL). With MASAL, we are able to perform analysis of genome-wide data with longitudinal phenotypes and covariates, making it possible to identify genes, gene-gene, and gene-environment (including time) interactions associated with the trait of interest. We conducted a permutation test to assess the associations between MASAL selected markers and triglycerides trait and report significant gene-gene and gene-environment interaction effects on the trait of interest.
منابع مشابه
Genome-wide association analysis of cardiovascular-related quantitative traits in the Framingham Heart Study
Multivariate linear growth curves were used to model high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and systolic blood pressure (SBP) measured during four exams from 1659 independent individuals from the Framingham Heart Study. The slopes and intercepts from each of two phenotype models were tested for association with 348,053 autosomal single-nucleotide poly...
متن کاملFlexible semiparametric analysis of longitudinal genetic studies by reduced rank smoothing.
In family-based longitudinal genetic studies, investigators collect repeated measurements on a trait that changes with time along with genetic markers. Since repeated measurements are nested within subjects and subjects are nested within families, both the subject-level and measurement-level correlations must be taken into account in the statistical analysis to achieve more accurate estimation....
متن کاملESTIMATING DRYING SHRINKAGE OF CONCRETE USING A MULTIVARIATE ADAPTIVE REGRESSION SPLINES APPROACH
In the present study, the multivariate adaptive regression splines (MARS) technique is employed to estimate the drying shrinkage of concrete. To this purpose, a very big database (RILEM Data Bank) from different experimental studies is used. Several effective parameters such as the age of onset of shrinkage measurement, age at start of drying, the ratio of the volume of the sample on its drying...
متن کاملGENETIC PROGRAMMING AND MULTIVARIATE ADAPTIVE REGRESION SPLINES FOR PRIDICTION OF BRIDGE RISKS AND COMPARISION OF PERFORMANCES
In this paper, two different data driven models, genetic programming (GP) and multivariate adoptive regression splines (MARS), have been adopted to create the models for prediction of bridge risk score. Input parameters of bridge risks consists of safe risk rating (SRR), functional risk rating (FRR), sustainability risk rating (SUR), environmental risk rating (ERR) and target output. The total ...
متن کاملBayesian Group Lasso for Nonparametric Varying-coefficient Models with Application to Functional Genome-wide Association Studies.
Although genome-wide association studies (GWAS) have proven powerful for comprehending the genetic architecture of complex traits, they are challenged by a high dimension of single-nucleotide polymorphisms (SNPs) as predictors, the presence of complex environmental factors, and longitudinal or functional natures of many complex traits or diseases. To address these challenges, we propose a high-...
متن کامل