Pathogenesis of Generalized Dermal Pigmentation Secondary to Malignant Melanoma and Melanuria*
نویسنده
چکیده
One of the most striking phenomena in human oncology is the transformation of the normal skin color to an intense blue-gray pigmentation. This occurs as a complication of malignant melanoma. In the recent literature, several excellent examples of this type of pigmentation have been reported in patients with malignant melanoma. In this paper we report on another patient with generalized melanin pigmentation and malignant melanoma. The pathogenesis of the pigmentation in this disorder will be discussed in light of present knowledge of the biochemistry of human melanogenesis (1).
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