Brief Communication Activation of NR2A-Containing NMDA Receptors Is Not Obligatory for NMDA Receptor-Dependent Long-Term Potentiation
نویسندگان
چکیده
Carl Weitlauf,1* Yumiko Honse,4* Yves P. Auberson,5 Masayoshi Mishina,6 David M. Lovinger,4 and Danny G. Winder1,2,3 1Center for Molecular Neuroscience, 2Department of Molecular Physiology and Biophysics, and 3J. F. Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, 4Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, 5Novartis Laboratories, CH-4002 Basel, Switzerland, and 6University of Tokyo, Tokyo 113-0033, Japan
منابع مشابه
P6: Metabotropic Glutamate Receptor-Dependent Role in the Formation of Long-Term Potentiation
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Activation and Thr286 autophosphorylation of calcium/calmodulindependent kinase II (CaMKII) following Ca2+ influx via N-methyl-D-aspartate (NMDA)-type glutamate receptors is essential for hippocampal long term potentiation (LTP), a widely investigated cellular model of learning and memory. Here, we show that NR2B, but not NR2A or NR1, subunits of NMDA receptors are responsible for autophosphory...
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