Free plasma 11-hydroxycorticosteroids in patients with adrenocortical disorders.

The effect of intravenously-administered ACTH on plasma 17,21-dihydroxy-20-ketosteroids in normal individuals and in patients with disorders of the adrenal cortex.

The response of the adrenal cortex to exogenous ACTH has been recognized as one of the more specific and quantitative tests of adrenal function (1). Changes in the 24-hour excretion values of urinary 17-ketosteroids and 17-hydroxycorticosteroids during ACTH administration have proved to be valuable indices of adrenocortical capacity (2, 3). With the development of technics for the chemical esti...

Adrenocortical function in obesity and Cushing's syndrome.

1. The 24 h urinary excretions of Porter-Silber (P-S) chromogens, 17-hydroxycorticosteroids (17-OHCS) and free cortisol, and day-night variation of plasma P-S chromogens, were studied in normal and obese women and patients with a confirmed diagnosis of Cushing’s syndrome. 2. The mean absolute values of P-S chromogens, 17-OHCS and free cortisol were similar for the normal and obese subjects and ...

Circadian rhythm of plasma 11-hydroxycorticosteroids in psychiatric disorders.

Studies of the circadian rhythm in plasma 11-O.H.C.S. levels showed that a subgroup of affective psychotics had higher plasma 11-OHCS values as compared with schizophrenic and other psychotic subgroups, and a somewhat less regular rhythm. One patient with depression who was studied over 48-hour periods showed a reduction in plasma 11-OHCS levels with clinical recovery. An accentuated fall and r...

Changes in plasma levels of 17-hydroxycorticosteroids during the intravenous administration of ACTH. I. A test of adrenocortical capacity in the human.

Cortisol Levels in Protein-calorie Malnutrition

The two clinical syndromes of protein-calorie malnutrition-kwashiorkor and marasmus, have been widely studied. Striking differences have been observed between kwashiorkor and marasmus, both with respect to the clinical picture and the biochemical profile. One such difference is the exaggerated hyperglycaemic response of the marasmic infant to epinephrine in contrast to the poor response of the ...