Predicting survival and leukemic evolution in patients with myelodysplastic syndrome.
نویسندگان
چکیده
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منابع مشابه
Risk stratification based on both disease status and extra-hematologic comorbidities in patients with myelodysplastic syndrome.
The incidence of myelodysplastic syndromes increases with age and a high prevalence of co-morbid conditions has been reported in these patients. So far, risk assessment in myelodysplastic syndromes has been mainly based on disease status. We studied the prognostic impact of comorbidity on the natural history of myelodysplastic syndrome with the aim of developing novel tools for risk assessment....
متن کاملA case of myelodysplastic syndrome with a der(1;18)(q10;q10) translocation
Fig. 1. (A) A nuclear-budding and megalocytic orthonormoblast representing dyserythropoiesis (Wright stain, ×1,000). (B) G-banded karyogram of bone marrow cells. The arrow indicates the der(1;18)(q10;q10) chromosome. prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol 2007; 25:3503-10. 10. Niscola P, Vischini G, Tendas A, et al. Ma...
متن کاملPrognostic factors in myelodysplastic syndromes.
UNLABELLED BACKGROUND Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cell and are characterized by ineffective hematopoiesis with normo- or hyper cellular bone marrow and cytopenia(s).The natural evolution of the disease consists of bone marrow failure (leading to infectious and hemorrhagic episodes or anemia related complications) and transformation to acute myel...
متن کاملRange Determination of Antigen Expression in Myeloid, Erythroid and Lymphoid Cell Lineages among Patients with Myelodysplastic Syndrome
Background: Myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. Understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. Patients and Methods: We compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome ...
متن کاملMyeloid Cell Leukemia-1 Gene Expression and Clinicopathological Features in Myelodysplastic Syndrome
Background and Aims: Myeloid cell leukemia-1 (Mcl-1) plays a pivotal role in the survival of hematologic and solid tumors, and is known as a substantial oncogene. Studies have demonstrated the altered expression of Mcl-1 has been linked to malignancy development and poor prognosis. In this research, we have studied the expression of Mcl-1 mRNA in myelodysplastic syndrome (MDS) patients and det...
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ورودعنوان ژورنال:
- Haematologica
دوره 91 12 شماره
صفحات -
تاریخ انتشار 2006