Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice.

Genetic resistance to murine cryptococcosis: the beige mutation (Chédiak-Higashi syndrome) in mice.

The influence of the bgJ and bg2J mutations on the susceptibility of mice to experimental cryptococcosis was studied in inbred mice of the C57BL/6J and C3H/HeJ strains. Although infected animals with the bg/bg genotype had a significantly shorter lifespan than bg/+ or +/+ animals, C3H/He beige-2J mice were less susceptible than C57BL/6 beige-J mice when compared with nonbeige mice of similar ba...

Beige rat: a new animal model of Chediak-Higashi syndrome.

Although Chediak-Higashi syndrome (CHS) has been found in various mammalian species, it has not been described in rats. Since giant granules characterizing CHS are easily recognizable in mast cells of beige (CHS) mice, we screened mast-cell granules in the auricle of some mutant rats, of which coat color was diluted by mutation. Giant granules of mast cells were found in a mutant trait that occ...

Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice.

Previously, we have shown in a model of hypersensitivity pneumonitis that Th1-biased C57BL/6 mice are susceptible and Th2-biased DBA/2 mice are resistant to disease. We also showed that this was explained in part by differential regulation of IL-12 by IL-4. For these reasons, we postulated that C57BL/6 and DBA/2 mice differentially express IL-4. In this study, we show that C57BL/6 immune cells ...

Spontaneous hemorrhagic diathesis in inbred mice due to single or multiple "prothrombin-complex" deficiencies.

Relative immunologic capacity of leukemic and low-leukemic strains of mice to resist infection.

A comparative study was made to determine whether young mice predisposed to a high incidence of spontaneous leukemia displayed a distinctive response to infection which could be related to either a hyperactivity of their reticuloendothelial system (RES) or, conversely, some immunologic deficiency. The relative susceptibility to experimental infection of young mice (7-10 weeks old) of '"leukemic...