Metal transport across biomembranes: emerging models for a distinct chemistry.

A potential mechanism of a cationic cyclopeptide for enhancing insulin delivery across Caco-2 cell monolayers.

Effective delivery of therapeutic biomolecules across biomembranes is a challenging topic. A cationic cyclopeptide named TD-34 (ACSSKKSKHCG) was reported to improve insulin delivery across biomembranes effectively. Based on our previous work, we investigated the mechanism of TD-34 for enhancing insulin across Caco-2 cell monolayers. Transport studies of insulin, TD-34 and insulin accompanied wi...

Solvent Extraction and Transport of Rare Earth Metal Ions Using 5.11.17.23-Tetra-tert-butyl-25,27-bis (diethylcarbomoylmethoxy)-26,28-dihydroxy Calix[4]arene

The solvent extraction of rare earth metal ions from nitrate solutions by 5.11.17.23-tetra-tert-butyl-25,27-bis(diethylcarbamoylmethoxy)-26,28-dihydroxycalix[4]arene (L) in 1,2-dichloroethane has been investigated. The alalysis of the extraction equilibrium obtained from a mixture of La3+, Eu3+, Er3+ and Y3+ revealed that the extracted species hav...

Application of Radioisotopes in Biochemical Analyses: Metal Binding Proteins and Metal Transporters

Radioisotopes (RI) such as 3H, 14C, 32P, and 45Ca are excellent tools in biological research. Most RI are used as tracers in studies of primary and secondary metabolism, drug metabolism, transcription, translation, post-translational modifications such as protein phosphorylation, association of proteins with metals, and transport of metals across biomembranes. Furthermore, some experiments have...

Mechanism of the translocation step of mediated transport across biomembranes: In favour of the allosteric model

Epithelial Calcium and Phosphate Transport: Molecular and Cellular Aspects

This contains the proceedings of the Second International Workshop on Calcium and Phosphate Transport across Biomembranes, held in Vienna in March 1984. It consists of 58 short articles, reproduced photographically from typescript. These deal with a variety of topics, including Ca2+-ATPase, Na-Ca exchange and the measurement of intracellular free Ca2+. Strictly speaking, only about half of the ...