Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.
نویسندگان
چکیده
The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.
منابع مشابه
Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 2 شماره
صفحات -
تاریخ انتشار 2007