Breast Cancer: Radioimmunoscintigraphy and Radioimmunotherapy
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منابع مشابه
Kinetic analysis and probability mapping applied to the detection of ovarian cancer by radioimmunoscintigraphy.
Kinetic analysis with probability mapping is an objective method of serial image analysis applicable to radioimmunoscintigraphy. The technique is described and subjected to clinical testing by comparing the prediction of biopsy histology from the probability map in patients coming to operation. In those with ovarian cancer undergoing second-look laparotomy after completing full courses of chemo...
متن کاملRadioimmunoscintigraphy of Breast Cancer
Breast cancer has become one of the leading causes of death in women today. Many researches are ongoing to develop more effective imaging methods for early diagnosis of breast cancer. The application of nuclear medicine techniques to study patients with breast cancer has recently raised its profile, particularly in the investigation ‘indeterminate mammographic lesions’. Radio labeled monoclonal...
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Radiolabeled monoclonal antibodies (MAbs) can add a dimension to diagnostic imaging and staging of metastatic head and neck cancer, as well as in eradication of this disease. The vast majority of malignancies arising in the oral cavity, pharynx and larynx are squamous cell carcinomas. This common cellular origin makes it attractive to search for appropriate tumor-associated antigens, which are ...
متن کاملRadioimmunotherapy of human B-cell lymphoma with 90Y-conjugated antiidiotype monoclonal antibody.
We report the first case of 90Y-conjugated monoclonal antibody (MoAb) administration for human radioimmunotherapy. Ten mCi 90Y-labeled antiidiotype (anti-Id) MoAb were administered to a patient with B-cell lymphoma whose tumor successfully imaged with 111In-labeled anti-Id MoAb. No significant toxicities were observed. More than 2 g of unlabeled anti-Id MoAb were administered while clearing the...
متن کاملHigh-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium-111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human anti-mouse antibody.
PURPOSE Although radioimmunotherapy alone is effective in lymphoma, its application to solid tumors will likely require a combined modality approach. In these phase I studies, paclitaxel was combined with radioimmunotherapy in patients with metastatic hormone-refractory prostate cancer or advanced breast cancer. EXPERIMENTAL DESIGN Patients were imaged with indium-111 (111In)-1,4,7,10-tetraaz...
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