The inhibition of the fatty acid oxygenase of sheep vesicular gland by antioxidants.

Antioxidants inhibit the fatty acid oxygenase of sheep vesicular gland and soybean lipoxygenase in an ins~~n~us, reversible manner. Their in~bito~ effectiveness was not related to their traditional antioxidant potencies but seemed to depend on the nature of the enzyme. The destructive effect of eicosa-58, I I, +tetraynoic acid, a substrate analog, on vesicular gland oxygenase could be prevented in the presence of either a-naphthol or 2,z,4-t~m~hyl-~ethox~I,2~ihydroquino~ne (Santoquin).