Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.
نویسندگان
چکیده
MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including beta-lactams targeted to the periplasm.
منابع مشابه
Investigation of MexAB-OprM efflux pump gene expression in clinical isolates of pseudomonas aeruginosa isolated from Intensive Care Unit
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 41 9 شماره
صفحات -
تاریخ انتشار 1997