α−Lipoic Acid: Biological Effects and Clinical Implications

α−Lipoic acid is unique in its ability to act as an antioxidant in fatand watersoluble tissues in both its oxidized and reduced forms. It is readily absorbed from an oral dose. Because of its myriad biological activities, including an ability to chelate metals and to scavenge a wide array of free radicals, α−lipoic acid is considered by several experts to be an ideal antioxidant. Clinical applications for this nutrient include the following conditions: diabetic polyneuropathy, cataracts, glaucoma, ischemia− reperfusion injury, and Amanita mushroom poisoning. Because of its unique characteristics α−lipoic acid is likely to have therapeutic application in a wide range of additional clinical conditions. (Alt Med Rev 1997; 2(3):177-183)