Preclinical Evaluation of New Drug-Eluting Biodegradable Poly-D/L-lactic Acid Vascular Stent
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Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease
This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 m...
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Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in biomedical application owing to its well categorized biodegradable prop...
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Correspondence to Stéphane Cook; [email protected] THE BIORESORBABLE VASCULAR SCAFFOLDS ‘BVS’ The main limitation of percutaneous coronary intervention compared to open-heart surgery is the insertion of a foreign body (usually a stent) inside the coronary artery. This is associated with foreign body inflammation that triggers restenosis, neoatherosclerosis and late-occurring stent thrombos...
متن کاملModeling and analysis of drug-eluting stents with biodegradable PLGA coating: consequences on intravascular drug delivery.
Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent...
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تاریخ انتشار 2008