comparison between effects of different doses of melissa officinalis and atorvastatin on the activity of liver enzymes in hypercholesterolemia rats

نویسندگان

ali zarei department of biology, unit of science research, islamic azad university of damghan, damghan, i.r. iran

saeed changizi ashtiyani department of physiology, arak university of medical sciences, arak, i. r. iran

soheila taheri deputy of research, arak university of medical sciences, arak, i. r. iran

fateme rasekh department of plant biology, payame-noor university, tehran, i. r. iran

چکیده

objectives: liver is one of the most sensitive tissues to oxidant damage. hence, the present study was conducted to compare the effects of melissa officinalis (mo) extract and atorvastatin on the activity of liver enzymes in rats. materials and methods: in this experimental study, 60 male wistar rats were selected and allocated to six groups (n=10). the control group received a normal diet, sham group received a fatty diet while other groups received a fatty diet and the alcoholic extract ofmo, at minimum (25 mg/kg), moderate (50 mg/kg), and maximum (75 mg/kg) doses (i.p.). the last group received atorvastatin (10 mg/kg) through gavage with a fatty diet over a 21-day period. at the end of this 21-day period, blood samples were drawn and the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), and alkaline phosphatase (alp), activity of liver enzymes as well as cholesterol in the samples were measured. results: the obtained results showed that the activity of liver enzymes in the treatment groups receiving mo extract and the group receiving atorvastatin decreased significantly. moextract reduced the level of liver enzymes. conclusion: therefore, further studies for obtaining a better understanding of the mechanism of effect of mo for treating liver diseases are recommended.

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منابع مشابه

Comparison between effects of different doses of Melissa officinalis and atorvastatin on the activity of liver enzymes in hypercholesterolemia rats

Objectives: Liver is one of the most sensitive tissues to oxidant damage. Hence, the present study was conducted to compare the effects of Melissa officinalis (MO) extract and Atorvastatin on the activity of liver enzymes in rats. Materials and Methods: In this experimental study, 60 male Wistar rats were selected and allocated to six groups (n=10). The control group received a normal diet, sha...

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Comparison between effects of different doses of Melissa officinalis and atorvastatin on the activity of liver enzymes in hypercholesterolemia rats

OBJECTIVES Liver is one of the most sensitive tissues to oxidant damage. Hence, the present study was conducted to compare the effects of Melissa officinalis (MO) extract and Atorvastatin on the activity of liver enzymes in rats. MATERIALS AND METHODS In this experimental study, 60 male Wistar rats were selected and allocated to six groups (n=10). The control group received a normal diet, sha...

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عنوان ژورنال:
avicenna journal of phytomedicine

جلد ۴، شماره ۱، صفحات ۱۵-۲۳

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