effects of nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial
نویسندگان
چکیده
objectives: nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. the aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of nigella sativa oil in patients with rheumatoid arthritis (ra). materials and methods: forty-two patients with ra were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. subjects in intervention group received two capsules, 500 mg each, of nigella sativa oil, each day for 8 weeks. the other group consumed two capsules as placebo per day for the same period of time. serum tnf-α, il-10, and whole blood levels of oxidative stress parameters were measured at baseline and end of the trial. results: the serum level of il-10 was increased in the nigella sativa group (p<0.01). moreover, treatment with nigella sativa led to significant reduction of serum mda and no compared with baseline (p<0.05). there were no significant differences in the tnf-α, sod, catalase, and tas values between or within the groups, before and after the intervention (p>0.05). conclusions: this study indicates that nigella sativa could improve inflammation and reduce oxidative stress in patients with ra. it is suggested that nigella sativa may be a beneficial adjunct therapy in this population of patients
منابع مشابه
Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial
Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid ar...
متن کاملEffects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial.
OBJECTIVE Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arth...
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متن کاملEffect of Nigella sativa oil extracts on inflammatory and oxidative stress markers in Behcet’s disease: A randomized, double-blind, placebo-controlled clinical trial
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متن کاملeffects of nigella sativa l. seed oil in type ii diabetic patients: a randomized, double-blind, placebo - controlled clinical trial
background: nigella sativa (n. sativa) seeds are used to treat diabetes mellitus in traditional medicine. moreover, n. sativa oil has reduced the fasting blood glucose level in non-diabetic volunteers. objective: the present study was undertaken to explore the possible anti-hyperglycemic effect of n. sativa oil in type ii diabetic patients. methods: a randomized clinical trial was conducted in ...
متن کاملEfficacy of Nigella sativa seeds oil in patients with Behcet’s disease: a double-blind randomized controlled trial
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عنوان ژورنال:
avicenna journal of phytomedicineجلد ۶، شماره ۱، صفحات ۳۴-۴۳
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