anti-proliferative and apoptotic effects of ziziphus jujube on cervical and breast cancer cells
نویسندگان
چکیده
objectives: ziziphus jujube (jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. this study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. materials and methods: the cervical ov2008 and breast mcf-7 cancer cells were incubated with different concentrations of jujube aqueous extraction (0-3 mg/ml) for various times (0-72 h). cell viability was assessed by trypan blue and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay. the expression of two apoptosis-related genes in treated cells evaluated by quantitative real time -pcr analysis. results: jujube significantly inhibited cancer cell viability in a dose- and time- dependent manner. herb-induced apoptosis was associated with enhanced expression of bax and decreased bcl2 gene leading eventually to a time-dependent six fold increase in the bax/bcl-2 ratio. conclusions: these results indicated that jujube may be a natural potential and promising agent to prevent or treat human cancers.
منابع مشابه
Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells
Objectives: Ziziphus Jujube (Jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. This study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. Materials and Methods: The cervical OV2008 and breast MCF-7 cancer cells were incubated with differ...
متن کاملAnti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells.
OBJECTIVE Ziziphus Jujube (Jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. This study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. MATERIALS AND METHODS The cervical OV2008 and breast MCF-7 cancer cells were incubated with differe...
متن کاملAnti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells (Short Communication)
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عنوان ژورنال:
avicenna journal of phytomedicineجلد ۶، شماره ۲، صفحات ۱۴۲-۱۴۸
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