epilepsy drug and effects on fetal development: potential mechanisms

نویسندگان

leila etemad department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

mohammad moshiri department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

seyed a moallem department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences and pharmaceutical sciences research center and medical toxicology research center, mashhad university of medical sciences, mashhad, iran

چکیده

normal 0 false false false en-us x-none ar-sa approximately 1% of all pregnancies are in woman with epilepsy. although, the majority of children born to women with epilepsy are normal, they are at increased risk for malformations. notably, the teratogenicity of antiepileptic drugs is a well-defined subject. the incidence of major malformations in offspring of mothers with epilepsy who were treated with aeds is higher than women with untreated epilepsy and in the general population. these malformations include spina bifida, cleft palate, limb reduction defects, cardiac abnormalities, hypospadias, and gastrointestinal atresia. the exact mechanism by which the aeds mediate abnormalities in the fetus is uncertain. however, there are several hypotheses to explain them. some of the most important include folate-related actions, ischemia, reactive intermediates (e.g., free radicals), and genetic susceptibility. thus, understanding the mechanisms of aed-related abnormalities is of vital importance for the care of epileptic women and their offspring.

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عنوان ژورنال:
journal of research in medical sciences

جلد ۱۷، شماره ۹، صفحات ۰-۰

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