serum levels of glucagon-like peptide (glp)-1 and glp-2 in patients with hashimoto’s thyroiditis

background: the influence of hashimoto’s thyroiditis (ht) with subclinical hypothyroidism or euthyroid status on the alteration of glucagon-like peptide (glp)-1 and glp-2 levels remains uncertain. materials and methods: twenty-four untreated ht patients with subclinical hypothyroidism, 24 euthyroid ht patients, and 24 age- and gender-matched controls were enrolled in the study. the levels of glp-1, glp-2, glucose, glycated albumin, insulin, thyroid hormone, and thyroid autoantibodies were measured and evaluated. results: the levels of glp-1, blood glucose, and triglyceride were higher in ht patients with subclinical hypothyroidism than in controls (all p < 0.05, respectively). however, the above variables, including glp-2, were similar in euthyroid patients and controls.neither glp-1 nor glp-2 was correlated with thyroid hormone, thyroid autoantibodies or metabolic parameters. conclusion: the serum levels of glp-1, not glp-2, were increased in patients with subclinical hypothyroidism. our data suggest that subclinical hypothyroidism affects circulating glp-1 levels.