dynamic simulation and control of a continuous bioreactor based on cell population balance model

Dynamic Simulation and Control of a Continuous Bioreactor Based on Cell Population Balance Model

Saccharomyces cerevisiae (baker’s yeast) can exhibit sustained oscillations during the operation in a continuous bioreactor that adversely affects its stability and productivity. Because of heterogeneous nature of cell populations, the cell population balance equation (PBE) can be used to capture the dynamic behavior of such cultures. In this work, an unstructured-segregated model is used f...

Dynamic Simulation and Control of Microbial Cell Population in Continuous Bioreactors

mortality forecasting based on lee-carter model

over the past decades a number of approaches have been applied for forecasting mortality. in 1992, a new method for long-run forecast of the level and age pattern of mortality was published by lee and carter. this method was welcomed by many authors so it was extended through a wider class of generalized, parametric and nonlinear model. this model represents one of the most influential recent d...

a study on rate making and required reserves determination in reinsurance market: a simulation

reinsurance is widely recognized as an important instrument in the capital management of an insurance company as well as its risk management tool. this thesis is intended to determine premium rates for different types of reinsurance policies. also, given the fact that the reinsurance coverage of every company depends upon its reserves, so different types of reserves and the method of their calc...

Pseudo Dynamic Model Reference Nonlinear Control of a Continuous Bioreactor with Input Multiplicities

In the present work, the model reference nonlinear controller (MRNC) based on pseudo dynamic model is designed to a continuous bioreactor which exhibits input multiplicities in dilution rate on productivity. i.e., two values of dilution rate will give the same value of productivity. The performance of MRNC and linear PI controller have been evaluated through simulation studies. The optimal para...

Measuring a Dynamic Efficiency Based on MONLP Model under DEA Control

Data envelopment analysis (DEA) is a common technique in measuring the relative efficiency of a set of decision making units (DMUs) with multiple inputs and multiple outputs. ‎‎Standard DEA models are ‎‎quite limited models‎, ‎in the sense that they do not consider a DMU ‎‎at different times‎. ‎To resolve this problem‎, ‎DEA models with dynamic ‎‎structures have been proposed‎.‎In a recent pape...