study of ige in children with steroids responsive nephrosis

objectives: the idiopathic minimal change nephritic syndrome (nephrosis) is responsible in 80% of nephritic syndromes in children. it is a clinical entity characterized by inter and outer renal parameters. main factor in glomerolar damages is proteinuria and the role of ige is possible. aim: in this research, serum ige concentrations were measured in children with nephrosis in three stages: relapse, remission in treatment with steroids, remissions after treatment with steroids. materials and methods: study was done on children under 16 years old that suffered from nephrosis. they treated with prednisolone. serum ige concentrations were measured by elisa technique. results: average concentration of serum ige in the relapse phase was 274.8 iu/ml (sd=14.6); it was in the remission with steroids treatments 179.59 iu/ml (sd= 14.82) and it was 234. 9 iu/ml (sd=14.58) in the remission phase after treatment with steroids. conclusion: in some cases ige is significantly reduced after steroid treatment therefore it seems possible that allergic agents can trigger or increase the disease. serum ige concentration was not a main factor in nephritic syndrome.