fasting hyperglycemia and insulin resistance in colorectal adenomatous polyps

objectives: to investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. materials and methods: in this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (igf-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with adenomatous polyps). we also estimated homeostasis model assessment insulin resistance index (homa-ir) in two groups. statistical analyses were performed using the student t-test and chi-square test. for all tests a p value ≤ 0.05 was considered to be statistically significant. results: the mean of waist circumference (p < 0.01), waist to hip ratio (p < 0.01), fasting serum glucose (p < 0.05), total cholesterol (p < 0.05), and ldl (p < 0.05) were significantly higher in patients with adenomatous polyps. the mean of hdl was significantly lower in patients with adenomatous polyps (p < 0.01). there was no relation between fasting serum insulin, igf-1 and glucose tolerance test with adenomatous polyps. hence homa-ir was higher in patients with adenomatous polyps (2.9 ± 2.6 vs. 2.82 ± 2.1), this difference was not significant statistically. conclusion: fasting hyperglycemia could be a risk factor to adenomatous polyps’ development. although this study did not show any relation between insulin resistance index and adenomatous polyps, further studies are needed for more evaluation.