clinicopathologic characteristics and outcome of childhood and adolescent ewing’s sarcoma in center of iran

نویسندگان

اخوان

a akhavan department of radiotherapy,isfahan university of medical sciences,isfahan,iran بینش

f binesh department of pathology,shahid sadoughi university of medical sciences,yazd,iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (isfahan university of medical sciences) هاشمی

a hashemi department of pediatric medicine, shahid sadoughi university of medical sciences,yazd,iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences) شمشیری

h shamshiri general practitioner, shahid sadoughi university of medical sciences, yazd, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences)

چکیده

background ewing’s sarcoma family is a group of small round cells tumors. the aim of this study is to evaluate clinicopathologic characteristics and outcome of ewing’s sarcoma in children and adolescents in yazd, iran. materials and methods all patients under 19 years with documented pathology of ewing’s sarcoma family tumor who referred to shahid ramazanzadeh radiotherapy center between 2002 to 2010 were enrolled in this retrospective study. overall survival and disease free survival and prognostic factors were evaluated. results among approximately 80,000 patients who referred to shahid sadoughi pathology department, over an 8-year period, the total number of patients with ewing sarcoma was 32, of which, 18 cases were under the age 19 . the mean age was 13.72 years. five patients (27.8%) had metastatic disease at the time of diagnosis. complete response had been achieved in 8 (44.4%) of the patients. local recurrence occurred in 4 (22.2%) of the patients. during the follow up 13 (72.2%) of the patients showed metastases. the mean overall survival was 34.79 months (95% ci: 22.27-47.32) .one, two, four and five year survival was 72%, 39%, 25% and 17% respectively. complete remission occurred in 10 patients (63.6%). a trend of better overall survival was found in these patients (p=0. 55). when the brain and bone metastases occurred, the overall survival decreased significantly (p=0. 003 ). conclusions the overall survival rate of ewing's sarcoma is very low in comparison with other parts of the world.

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Clinicopathologic characteristics and outcome of childhood and adolescent Ewing’s sarcoma in center of Iran

Background Ewing’s sarcoma family is a group of small round cells tumors. The aim of this study is to evaluate clinicopathologic characteristics and outcome of Ewing’s sarcoma in children and adolescents in Yazd, Iran. Materials and Methods All patients under 19 years with documented pathology of Ewing’s sarcoma family tumor who referred to Shahid Ramazanzadeh Radiotherapy center between 2...

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Clinicopathologic characteristics and outcome of childhood and adolescent Ewing’s sarcoma in center of Iran

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عنوان ژورنال:
iranian journal of pediatric hematology and oncology

جلد ۴، شماره ۳، صفحات ۹۷-۱۰۲

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