ca-125 in normal pregnancy and threatened abortion
نویسندگان
چکیده
background: ca-125 is a glycoprotein and its origin is uncertain during pregnancy. it arises during the first trimester and return to a non-pregnancy range in late pregnancy. objective: the aim of this study was to compare ca-125 level in threatened abortion and normal pregnancy less than 20 weeks of pregnancy. materials and methods: this was a prospective case study carried out on 50 healthy pregnant (group 1) and 50 threatened abortion women (group 2). we compared the levels of ca-125 in these groups and followed them to be informed of the outcome of pregnancy. results: fifty percent of women were in 20-24 years old group, primigravida and in the first trimester of pregnancy. the mean level of ca-125 in group 1 was 26.2 ± 3.25 iu/ml and in group 2 was 37.44 ± 2.72 iu/ml. the mean level of ca-125 in finally aborted patients was 58.17±7.25 iu/ml and in normal pregnant women, who continue to term, was 26.61±1.76 iu/ml. the ca-125 level in threatened women,whose pregnancy continued and did not abort, was 30.89 iu/ml. there was statistically significant difference between mean serum ca-125 levels of two groups (p < 0.05), while there was no statistically significant difference between these levels in the patients of both groups who continued pregnancies (p > 0.1). in group 2, there was a statistically significant difference in the level of ca-125 between those who developed abortion and those whose pregnancy continued but not aborted (p < 0.05). conclusion: measurement of serum ca-125 may be an inexpensive, easily available, sensitive and specific predictor of outcome in threatened abortion, which results the loss of pregnancy.
منابع مشابه
Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage
Background The aim of this study was to evaluate the relationship between ultrasonographic findings and serum progesterone and cancer antigen-125 (CA-125) levels in threatened miscarriage and to predict pregnancy outcome. MaterialsAndMethods In a prospective comparative case-control study, serum CA-125 and progesterone levels were measured for 100 pregnant women with threatened miscarriage who ...
متن کاملOutcome of pregnancy complicated by threatened abortion.
BACKGROUND Threatened abortion is the most common complication in the first half of pregnancy. Most of these pregnancies continue to term with or without treatment. Spontaneous abortion occurs in less than 30% of these women. Threatened abortion had been shown to be associated with increased incidence of antepartum haemorrhage, preterm labour and intra uterine growth retardation. OBJECTIVE Th...
متن کاملcorrelation of serum ca-125 and progesterone levels with ultrasound markers in the prediction of pregnancy outcome in threatened miscarriage
background: the aim of this study was to evaluate the relationship between ultrasonographic findings and serum progesterone and cancer antigen-125 (ca-125) levels in threatened miscarriage and to predict pregnancy outcome. materials and methods: in a prospective comparative case-control study, serum ca-125 and progesterone levels were measured for 100 pregnant women with threatened miscarriage ...
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متن کاملThe outcome of pregnancy complicated by threatened abortion.
E N a previous publication (Walker and Turnbull, 1953) we reported that in 14 pregnancies, in which there had been a history of threatened abortion, the haemoglobin and red cell levels in the baby’s cord blood at birth were higher than normal. From other evidence in the same paper we concluded that this was an indication that the supply of oxygen to the foetus was defective. If bleeding in the ...
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عنوان ژورنال:
international journal of reproductive biomedicineجلد ۵، شماره ۲، صفحات ۵۷-۰
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