the relationship between clinicobiochemical markers and depression in women with polycystic ovary syndrome

background: previous studies have demonstrated that clinical features of 16tpolycystic ovary syndrome16t (pcos) are associated with a lower degree of health, self, and sex satisfaction. objective: our study aimed to investigate possible associations between depression and different clinicobiochemical markers of pcos. materials and methods: in a cross-sectional analytic study, 120 pcos women aged 18-45 yr, were enrolled. beck depression inventory was used to assess depression. also, all participants underwent biochemical studies. individuals with 15 points and more in beck test were referred to a psychiatrist to participate in a complementary interview for the diagnosis of depression based on diagnostic and statistical manual of mental disorders iv (dsmiv-tr) criteria. results: among the study participants, 82 women (68.3%) were non-depressed, and 38 patients (31.7%) had some degrees of depression. according to the psychiatric interview, 10 patients (8.3%) had major depression, 22 patients (18.3%) had minor depression and 6 patients (5%) had dysthymia. we failed to show any significant difference in body mass index, hirsutism, infertility, serum total testosterone, lipid profile, and the homeostasis model assessment of insulin resistance (homa-ir) between depressed and non-depressed subjects (p>0.05). using spearman correlation, we did not find a positive correlation between bdi scores and clinicobiochemical markers for all pcos subjects (-0.139≤r≤+0.121, p>0.05). conclusion: in spite of high rate of depression in women with pcos, there was no significant association between clinicobiochemical markers and depression.