evaluation of selected thrombotic factors among pregnant women with preeclampsia and normal pregnant women

background: 63tpreeclampsia63t is one of the 63tcommon complications63t 63tduring63t 63tpregnancy with63t 63tconsiderable maternal and fetal63t 63tmortality63t 63tand63t 63tmorbidity63t. 63thypercoagulability63t 63tdue to63t 63tthrombophilic63t 63tfactors63t 63tis63t 63tdiscussed as the etiology involved in63t 63tthis disease63t. objective: 63tthe aim of this study63t was to evaluate 63tselected thrombotic factors among pregnant women with preeclampsia and normal pregnant women63t. materials and methods: 63tthis63t 63tcase-control63t 63tstudy63t was performed 63ton63t 63t200 pregnant women63t 63tat63t 63tthird trimester63t 63tof pregnancy between 2012 and 2013.63t 63t100 pregnant women63t 63tadmitted to63t qaem and imam reza hospitals of mashhad, due to preeclampsia, were selected as 63tcase group63t 63tand63t 63t10063t 63tpregnant women63t 63twithout preeclampsia63t referred to ob/gyn 63tclinic63t of these hospitals as 63tcontrol group. blood samples63t were taken from two groups for evaluation of the 63tcoagulation factors63t including 63tfactor v63t 63tleiden63t, 63tprotein63t 63tc,63t 63tprotein63t 63ts,63t 63tantithrombin63t 63tiii,63t 63tanti-63tcardiolipin 63tantibodies63t, and lupus 63tanticoagulant63t 63tantibodies63t. results: 63ttwo groups were not significantly different63t 63tin63t 63tterms of63t 63tmaternal age and63t 63tparity63t 63t(p>0.05).63t 63tlevels of factor63t 63tv63t 63tleiden63t, 63tprotein63t 63tc,63t 63tprotein63t 63ts, antithrombin63t 63tiii,63t 63tanti-63tcardiolipin 63tantibodies63t and lupus 63tanticoagulant63t 63tantibodies63t 63twere63t 63tcompared between63t 63ttwo groups63t. the 63tnumber63t 63tof patients with abnormal factor v leiden and63t 63tprotein63t 63tc63t 63twas63t 63tsignificantly higher63t 63tin63t 63tcase group than63t 63tin63t 63tthe control63t 63tgroup63t 63t(63tp<0.01 respectively), but other 63tfactors63t 63twere63t not 63tsignificant different between two groups.63t 63tthrombophilia63t 63tdisorders63t 63twere significantly63t 63tmore in case group63t compared to control 63t(p<0.001)63t. conclusion: 63tthe63t 63trisk of63t 63tthrombophilia63t 63tdisorders63t is higher 63tin63t 63tpreeclamptic63t 63tpatients than63t 63tnormal63t 63tpregnant women63t