effect of gabapentin on morphine consumption and pain after surgical debridement of burn wounds:a double-blind randomized clinical trial study
نویسندگان
چکیده
background burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself. uncontrolled acute burn pain increases the stress response and the incidence of chronic pain and associated depression. although opiates are excellent analgesics, they do not effectively prevent central sensitization to pain. the anticonvulsant gabapentin has been proven effective for treating neuropathic pain in large placebo-controlled clinical trials. experimental and clinical studies have demonstrated antihyperalgesic effects in models with central neuronal sensitization. it has been suggested that central neuronal sensitization may play an important role in postoperative pain. results all the enrolled patients were able to complete the study; therefore, data from 50 patients wereanalyzed. the vas scores at rest andduring movement at 1,4,8,12,16,20, and 24 h after the operation were significantly lower in the gabapentin group than in the placebo group (p < 0.05). morphine consumption was significantly lessr in the gabapentin group than in the placebo group (p < 0.05). sedation scores were similar in the 2 groups at all measured times. there were no differences in adverse effects between the groups. conclusions a single oral dose of 1200mg gabapentin resulted in a substantial reduction in postoperative morphine consumption and pain scores after surgical debridement in burn patients. objectives the aim of this study was to investigate the effect of gabapentin on morphine consumption and postoperative pain in burn patients undergoing resection of burn wounds. patients and methods
منابع مشابه
Effect of Gabapentin on Morphine Consumption and Pain after Surgical Debridement of Burn Wounds: A Double-Blind Randomized Clinical Trial Study
BACKGROUND Burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself. Uncontrolled acute burn pain increases the stress response and the incidence of chronic pain and associated depression. Although opiates are excellent analgesics, they do not effectively prevent central sensitization to pain. The anticonvulsan...
متن کاملEffect of Gabapentin on morphine demand and pain after laparoscopic sterilization using Filshie clips. A double blind randomized clinical trial
BACKGROUND A considerable number of patients require opioids during recovery after laparoscopic sterilization. This implies nausea, dizziness and sedation and increases the number of unplanned admissions. Gabapentin has shown excellent postoperative analgesic effect in a number of recent studies with few side effects. This study was designed to test whether gabapentin given preoperatively can r...
متن کاملGabapentin for Pain Control After Surgical Debridement of Burn Wounds
I read with great interest the contribution “Effect of Gabapentin on Morphine Consumption and Pain after Surgical Debridement of Burn Wounds: A Double-Blind Randomized Clinical Trial Study” by Raziet al. (1). Carrying out a Randomized Controlled Trial without funding and especially in our region is an uphill task indeed. I must therefore congratulate the authors on this achievement. The trial h...
متن کاملEffect of acupuncture on the pain of patients with acute low back pain: A randomized double-blind clinical trial study
Introduction: Low back pain is one of the most common causes of daily activity limitation and functional disabilities that affect a large number of people in the community. Due to the ineffectiveness of oral analgesics in relieving this type of pain and the need for their long-term use, which has its own side effects, the present study investigated the supplementary effect of acupuncture on pai...
متن کاملEvaluation of pretreatment with gelofen and novafen on pain relief after endodontic treatment; A double-blind randomized clinical trial study
Introduction: Feeling pain after root canal therapy has always been a major problem for patients and dentists. One of the suggested methods to manage the pain is using the prophylactic medication before treatment process. This study aimed at investigating the comparison of pretreatment with novafen versus gelofen on reducing the pain after root canal therapy. Materials &Methods: This double-...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
archives of trauma researchجلد ۱، شماره ۱، صفحات ۳۸-۴۳
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023