effect of gabapentin on morphine consumption and pain after surgical debridement of burn wounds:a double-blind randomized clinical trial study

نویسندگان

siamak rimaz anesthesiology research center, velayat university hospital, guilan university of medical sciences, rasht, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (guilan university of medical sciences)

cyrus emir alavi anesthesiology research center, velayat university hospital, guilan university of medical sciences, rasht, ir iran; anesthesiology research center, velayat university hospital, namjoo st., rasht, guilan province, ir iran. tel: +98-9111317398, fax: +98-1313245140سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (guilan university of medical sciences)

abbas sedighinejad anesthesiology research center, velayat university hospital, guilan university of medical sciences, rasht, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (guilan university of medical sciences)

mohammad tolouie department of burn surgery, velayat university hospital, guilan university of medical sciences, rasht, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (guilan university of medical sciences)

چکیده

background burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself. uncontrolled acute burn pain increases the stress response and the incidence of chronic pain and associated depression. although opiates are excellent analgesics, they do not effectively prevent central sensitization to pain. the anticonvulsant gabapentin has been proven effective for treating neuropathic pain in large placebo-controlled clinical trials. experimental and clinical studies have demonstrated antihyperalgesic effects in models with central neuronal sensitization. it has been suggested that central neuronal sensitization may play an important role in postoperative pain. results all the enrolled patients were able to complete the study; therefore, data from 50 patients wereanalyzed. the vas scores at rest andduring movement at 1,4,8,12,16,20, and 24 h after the operation were significantly lower in the gabapentin group than in the placebo group (p < 0.05). morphine consumption was significantly lessr in the gabapentin group than in the placebo group (p < 0.05). sedation scores were similar in the 2 groups at all measured times. there were no differences in adverse effects between the groups. conclusions a single oral dose of 1200mg gabapentin resulted in a substantial reduction in postoperative morphine consumption and pain scores after surgical debridement in burn patients. objectives the aim of this study was to investigate the effect of gabapentin on morphine consumption and postoperative pain in burn patients undergoing resection of burn wounds. patients and methods

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Effect of Gabapentin on Morphine Consumption and Pain after Surgical Debridement of Burn Wounds: A Double-Blind Randomized Clinical Trial Study

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archives of trauma research

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