serum antioxidant markers in patients with major and minor
نویسندگان
چکیده
introduction: in major b -thalassemia impaired biosynthesis of beta hemoglobin leads to accumulation of unpaired alpha hemoglobin chain. an iron overload generates oxygen-free radicals which ultimately leads to tissue injury. the aim of this investigation was to evaluate serum antioxidants in patients with major b -thalassemia and those with minor thalassemia in comparison with respective age and sex matched control groups. materials & methods: patients with major b -thalassemia or individuals with minor thalassemia (age range: 2-12 years and 29 -46 years, respectively; n=20 each) and 20 age and sex matched control subjects were recruited. serum glutathione (gsh) , superoxide dismutase and catalase (cat) were determined spectrophotometrically. data were analysed by t-test. results: glutathione levels were markedly lower in patients with b -thalassemia major than in the controls (p<0.05) whilst no differences were seen in either in the activities of catalase or superoxide dismutase. on the contrary, no differences were observed in individuals with minor thalassemia .when patients with major b -thalassemia and individuals with minor thalassemia were compared a marked reduction in gsh levels and increased in cat activity were noted in the patient group (p<0.05). conclusion: the data implies disturbance in antioxidant system in patients with major b -thalassemia as measured by a marked reduction of serum glutathione as the first line of defence against free radical attacks and increased in the activity of cat. this condition eventually leads to cellular tissue damage. antioxidant therapy may, therefore, prove useful in protecting against tissue damage.
منابع مشابه
Serum Antioxidant Levels in Children with Beta-Thalassemia Major
Background: Thalassemia represents a serious health problem in Iran because of its heterogeneous frequency and the existing endogamy system. It is an inherited blood disease characterized by the under production of normal hemoglobin, the oxygen-carrying protein in red blood cells. Materials and Methods: In this study, serum antioxidants including selenium (Se), zinc (Zn) and copper (Cu) were m...
متن کاملthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
The Comparison of Serum Vitamin D Level in Patients with Iron Deficiency Anemia and Minor Thalassemia
Abstract Background and Objective: Of the most common hypochromic microcytic anemia are iron deficiency anemia and minor thalassemia, which are common in Iran and their differential diagnosis is extremely important. The level of 25-hydroxy vitamin D is the indication of vitamin D blood status. The aim of this study was to compare serum levels of vitamin D in people with minor thalassemi...
متن کاملSerum Lipids in Turkish Patients with β-Thalassemia Major and β-Thalassemia Minor
Conflict of Interest: The authors of this paper have no conflicts of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included. References 1. Harteveld CL, Higgs DR. Alpha-thalassaemia. Orphanet J Rare Dis 2010;5:13. 2. Blackwell RQ, Jim RT, Tan TG, Weng MI, Liu CS, Wang CL. Hemoglobin G Waimanalo: alpha-64 Asp lead...
متن کاملSerum cancer antigen 15.3 concentrations in patients with beta-thalassemia minor compared to those with cancer and healthy in-dividuals
Background :Highserum level of cancer antigen 15.3 (CA15.3) has been reported in some malignant and nonmalignant conditions including thalassemia major which could have been resulted from ineffective erythropoiesis. We aimed to evaluate the serum level of CA15.3 in carriers of beta-thalassemia by comparing them with cancer patients and healthy individuals. Methods : This cross-sectional stu...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
مجله دانشگاه علوم پزشکی کرمانشاهجلد ۱۲، شماره ۱، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023