destructive effect of quinone-containing compounds on cytochrome p450: arbutin as a double-edged sword

Destructive effect of quinone-containing compounds on cytochrome P450: Arbutin as a double-edged sword

Destructive effect of quinone-containing compounds on cytochrome P450: Arbutin as a double-edged sword

I read with great interest the article by Khadir F et al. that was published in your prestigious journal discussing about the protective effects of arbutin on lipid peroxidation in cyclosporine-treated rats (1). The authors demonstrated that arbutin has protective effect against cyclosporine A (CsA)induced toxicity and further at dose 50 mg/kg/bw significantly neutralizes CsA-induced oxidative ...

Destructive Activism: The Double-Edged Sword of Digital Tactics

a group of websites in Estonia, including those of media outlets, government ministries, and banks, went oine. For three weeks, these sites were the target of a highly eective attack triggered by the government's controversial decision to move a Soviet war memorial. Similar attacks were experienced in August 2008, targeting Georgian websites during that country's conflict with Russia over the c...

A Double-Edged Sword?

The enormous benefits of inhibition of ACE demonstrate that manipulation of the metabolism of peptide hormones is a valuable therapeutic strategy for cardiovascular disease. Recent attempts to expand these benefits have combined ACE inhibition with inhibition of other peptidases such as neutral endopeptidase (NEP) in a single molecule, a strategy known as vasopeptidase inhibition. NEP metaboliz...

A Double-Edged Sword

Ischemic heart disease remains a leading cause of morbidity and mortality. The survival after acute ischemic events has improved substantially in recent years, but new syndromes have emerged. Cardiac remodeling following a large myocardial infarction, with dilatation of the left ventricle, has deleterious hemodynamic consequences and is a major cause of chronic heart failure.1 The increased inc...

Herbicides — A Double Edged Sword

Weeds represent a global agronomic problem that threatens the productivity of cultivated crops. Weeds compete with cultivated crops for the available moisture, nutrients and light. Consequently, weeds significantly reduce either crop yield or quality. Control of weeds is essential to maintaining the production of economic crops. Weed control may be achieved either through manual eradication or ...