detection of human papillomavirus-16 e6-oncoprotein in epithelial ovarian tumors samples of iraqi patients
نویسندگان
چکیده
conclusions hpv type 16 was detected in only 9.67% of malignant epithelial tumors. it appears that hpv infection plays a relatively minor role in the pathogenesis of ovarian carcinomas. results out of the eight cases with functional cysts only one case (12.5%) expressed hpv. no hpv expression was seen in cases with benign and borderline tumors. out of the 31 cases with one malignant surface epithelial ovarian tumor only three (9.67%) cases expressed hpv. there was no significant statistical difference in hpv expression among neoplastic and non-neoplastic ovarian tumors included in the present study (p= 0.476). patients and methods this was a retrospective study, which included 61 archived human ovarian tumor tissues embedded in paraffin blocks. the ovarian tumor tissues were divided into four groups. the first group was the malignant ovarian epithelial tumor group; it included 31 cases with invasive surface epithelial ovarian tumors. the second group was the borderline epithelial ovarian tumor group: it included four cases with borderline intermediate malignancy. the third group was the benign epithelial ovarian tumors group: it included 18 cases with benign epithelial ovarian tumors. the fourth group had functional ovarian cystic lesions: it included eight cases with non-neoplastic functional ovarian cysts. sections were made from each of the paraffin embedded blocks and examined using immunohistochemistry to detect hpv 16-e6-oncoprotein in ovarian tumor tissues. background human papillomavirus (hpv) is the causal factor for cervical cancer. however, the role of hpv infection in ovarian cancer is unclear. objectives this study aimed to determine the presence of human papillomavirus-16 (hpv-16) in ovarian tumor tissues.
منابع مشابه
Detection of Human Papillomavirus-16 E6-Oncoprotein in Epithelial Ovarian Tumors Samples of Iraqi Patients
BACKGROUND Human papillomavirus (HPV) is the causal factor for cervical cancer. However, the role of HPV infection in ovarian cancer is unclear. OBJECTIVES This study aimed to determine the presence of human papillomavirus-16 (HPV-16) in ovarian tumor tissues. PATIENTS AND METHODS This was a retrospective study, which included 61 Archived human ovarian tumor tissues embedded in paraffin blo...
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results out of 140 samples of oca, 70 (50%) samples were malignant cancer and 70 (50%) were benign cancer as the control group. out of 70 malignant samples 25 (36.0%) were hpv-16 positive. 2.8% of the tissue samples of the control group were positive for hpv-16. conclusions these results show a feasible role of hpv-16 in the carcinogenesis of oca. according to these results, infection with hpv ...
متن کاملDetection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples
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عنوان ژورنال:
jundishapur journal of microbiologyجلد ۷، شماره ۹، صفحات ۰-۰
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