interferon gamma gene polymorphism (+874 t > a) and chronic hepatitis b in the population of gorgan, north-eastern iran

نویسندگان

nadia ghasemian medical cellular & molecular research center, golestan university of medical sciences, gorgan, ir iran

majid shahbazi medical cellular & molecular research center, golestan university of medical sciences, gorgan, ir iran; medical cellular & molecular research center, golestan university of medical sciences, gorgan, ir iran. tel/fax: +98-1732421657

چکیده

results the frequencies of the aa, at, and tt genotypes were 31%, 51%, and 18% in the chronic hbv patient group, and 40%, 45%, and 15% in the healthy control group, respectively. however, a lack of association of the + 874 polymorphism in the ifn-γ gene of those with chronic hbv infection was found. evaluation of hbv association with this polymorphism was significant under the dominant genetic model (p = 0.04). conclusions ultimately, no association could be characterized between the polymorphism in ifn-γ + 874a/t and susceptibility to chronic hbv infection in this segment of the iranian population (p > 0.05). methods polymorphism detection analysis was performed on 598 subjects from north-eastern iran. the ifn-γ gene polymorphism (+ 874a/t) was genotyped through a specific sequence primer polymerase chain reaction (ssp-pcr). objectives this study was performed to investigate the relationship between the ifn-γ + 874 gene polymorphism and susceptibility to chronic hbv infection. background based on differences in individual immune responses to the hepatitis b virus (hbv), between 5% and 10% of patients become persistently infected with the virus, which leads to the determination of chronic hbv. cytokines such as interferon gamma (ifn-γ) are secretory proteins that play important roles in both innate and adaptive immune responses. functional studies have demonstrated that the ifn + 874a/t gene polymorphism can increase or decrease the overall expression of ifn-gamma (γ) and ultimately determine the outcome of the infection.

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Interferon Gamma Gene Polymorphism (+874 T > A) and Chronic Hepatitis B in the Population of Gorgan, North-Eastern Iran

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عنوان ژورنال:
jundishapur journal of microbiology

جلد ۹، شماره ۸، صفحات ۰-۰

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