synergistic antibacterial activity of plant peptide mbp-1 and silver nanoparticles combination on healing of infected wound due to staphylococcus aureus
نویسندگان
چکیده
conclusions the synergistic effect was found on the healing of infected wounds caused by s. aureus by using an mbp-1 and silver nanoparticles combination in a mouse model. results the mic and mbc of mbp-1 were found to be 0.6 and 0.7 mg/ml, respectively. mic and mbc of silver nanoparticles were determined to be 6.25 and 12.5 mg/l, respectively. mic and mbc of the silver nanoparticles and mbp-1 combination were found to be 3.125 mg/ml, 0.5 mg/l; and 6.25 mg/ml, 0.6 mg/l, respectively. the infected wound healed properly after the combined use of mbp-1 and silver nanoparticles. objectives the aim of this study was to investigate the synergistic antibacterial effect of plant peptide mbp-1 and silver nanoparticles on infected wounds caused by s. aureus. materials and methods the minimum inhibitory concentration (mic) and minimum bactericidal concentration (mbc) of mbp-1 and silver nanoparticles both on their own and in combination form were determined against s. aureus via macrodilution and microdilution methods. the synergistic antibacterial effect of silver nanoparticles and mbp-1 was investigated on infected wounds caused by s. aureus in a mouse model. background wound infection is a common problem in hospitals and is typically caused by the antibiotic-resistant staphylococcus aureus, which is a major pathogen for skin and soft tissue infections worldwide.
منابع مشابه
Synergistic Antibacterial Activity of Plant Peptide MBP-1 and Silver Nanoparticles Combination on Healing of Infected Wound Due to Staphylococcus aureus.
BACKGROUND Wound infection is a common problem in hospitals and is typically caused by the antibiotic-resistant Staphylococcus aureus, which is a major pathogen for skin and soft tissue infections worldwide. OBJECTIVES The aim of this study was to investigate the synergistic antibacterial effect of plant peptide MBP-1 and silver nanoparticles on infected wounds caused by S. aureus. MATERIAL...
متن کاملSynergistic antibacterial activity of chitosan-silver nanocomposites on Staphylococcus aureus.
The approach of combining different mechanisms of antibacterial action by designing hybrid nanomaterials provides a new paradigm in the fight against resistant bacteria. Here, we present a new method for the synthesis of silver nanoparticles enveloped in the biopolymer chitosan. The method aims at the production of bionanocomposites with enhanced antibacterial properties. We find that chitosan ...
متن کاملAntibacterial Activity of Origanum vulgare on Staphylococcus aureus in a Rat Model of Surgical Wound Infection
متن کامل
Effects of silver nanoparticles on Staphylococcus aureus contaminated open wounds healing in mice: An experimental study
The microorganisms have been noted as the main cause of delayed wound healing.The most common pathogen causing the wound infections is Staphylococcus aureus. Silver nanoparticles (AgNPs) show ample antibacterial activities. In the present study, the effect of AgNPs on mouse wounds inoculated with S. aureus was investigated. Sixty male mice (20 to 30 g) were anesthetized, full-...
متن کاملWound healing activity of Origanum vulgare against surgical wounds infected by Staphylococcus aureus in a rat model
Background: Wound infection has become a major medical problem in recent years. This is usually caused by Gram-positive bacteria, especially Staphylococcus aureus. Since antimicrobial resistance to current drugs has critically been developed in these causative microorganisms, substitution medicine has become one of the main interests within researchers. OBJECTIVES: The aim of this study was to...
متن کاملAntibacterial Activity of Silver Nanoparticles (AgNPs) in Staphylococcus aureus and Cytotoxicity Effect in Mammalian Cells
Staphylococcus aureus is a type of Gram-positive bacteria that can cause different healthcare-associated infections. Silver nanoparticles (AgNPs) are considered to be used in various applications against bacteria that are resistant to common antibiotics or even multiresistant bacteria as the S. aureus. This work evaluated the antimicrobial activity of AgNPs in strains of S. aureus resistant to ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
jundishapur journal of microbiologyجلد ۹، شماره ۱، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023