indoleamine 2,3-dioxygenase and immunological tolerance during pregnancy
نویسندگان
چکیده
indoleamine 2,3-dioxygenase (ido), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. ifn- γ is the main inducer of this enzyme. ido acts as an important defense mechanism of innate immunity against pathogens. it also has tumor suppressive activity and prolongs the survival of allograft. one of the interesting functions of ido is prevention of the allogenic fetus rejection during pregnancy by inhibiting alloreactive t cells. it was shown that inhibition of ido activity by ido inhibitor, 1-methyl tryptophan, during mouse pregnancy causes fetal rejection. the main mechanism by which ido protects fetus is through reducing the tryptophan level and suppressing the t cell activity in the feto-maternal interface. in this review the biological functions of ido with emphasis on its role in allogeneic fetus protection have been discussed.
منابع مشابه
Indoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy
Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN- γ is the main inducer of this enzyme. IDO acts as an important defense mechanism of innate immunity against pathogens. It also has tumor suppressive activity and prolong...
متن کاملIndoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy
Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN-γ is the main inducer of this enzyme. IDO acts as an important defense mechanism of innate immunity against pathogens. It also has tumor suppressive activity and prolongs...
متن کاملIndoleamine 2,3-dioxygenase: From tolerance during pregnancy to cancer
RESUMEN El feto expresa durante el embarazo antígenos procedentes del padre que no provocan el rechazo como cualquier otro injerto semi-alogénico. Entre los sistemas implicados en la inducción de la tolerancia materno-fetal, se encuentra la enzima indolamina 2,3-dioxigenasa (IDO) que inicia la degradación del triptófano. Al consumir el triptófano provoca una inhibición de la respuesta de las cé...
متن کاملIndoleamine 2,3-dioxygenase (ido) and Immune Tolerance
The IDO facilitates immune tolerance and is one of the main actors involved in the inhibition of cell proliferation, including activated T cells. IDO induces production of reactive oxygen species (ROS) and nitric oxide (NO) radicals. Several pathways involved in the regulation of immune response are regulated by redox mechanisms. Reactive oxygen and nitrogen species (ROSRNS) and other redox act...
متن کاملIndoleamine 2,3-dioxygenase and tumor-induced tolerance.
Tumors arise from normal cells of the body through genetic mutation. Although such genetic mutation often leads to the expression of abnormal antigens, the immune system fails to respond effectively to these antigens; that is, it is tolerant of these antigens. This acquired state of tolerance must be overcome for cancer immunotherapy to succeed. Indoleamine 2,3-dioxygenase (IDO) is one molecula...
متن کاملIndoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?
Cells expressing IDO suppress innate and adaptive immunity to promote tolerance by catabolizing the amino acid tryptophan (Trp) and other indole compounds. Interferon type I (IFN-I) and type II (IFN-II) produced at sites of inflammation or by activated immune cells are potent IDO inducers because mammalian IDO genes contain IFN response elements. Elevated IDO expression by dendritic cells (DCs)...
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عنوان ژورنال:
iranian journal of immunologyجلد ۱، شماره ۳، صفحات ۱۴۳-۱۵۳
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