association between hla-drb1*01 and hla-cw*08 and outcome following htlv-i infection
نویسندگان
چکیده
background: human t cell lymphotropic virus type i (htlv-i)-associated myelopa-thy/tropical spastic paraparesis (ham/tsp) is an inflammatory disease which occurs in less than 2% of htlv-i -infected individuals. high proviral load, high htlv-i-specific cd8+ cytotoxic t lymphocyte frequency (ctl) and host genetic factors such as hla all appear to be associated with htlv-i infection. previous studies have shown that hla-drb1*01 increases the risk of ham/tsp in japanese htlv-i infected individu-als. objective: to investigate the association between hla class ii drb1 alleles and hla class i alleles (hla-cw*08, b54, a*02 and a-30) in htlv-i infected individu-als in mashhad. methods: here we determined the frequency of hla class ii drb1, using inno-lipa reverse hybridization line probe assay, and hla class i alleles (hla-cw*08,b54, a*02 and a-30) by pcr-sscp method in healthy controls, ham/tsp patients and htlv-i infected individuals born and resident in mashhad. results: the frequency of hla-drb1*01 alleles in this population was different from other areas of iran. the frequency of hla-drb1*01 was significantly increased in ham/tsp patients compared with carriers (p 0.028; or=9.4). the frequency of hla-cw*08 was also significantly increased in ham/tsp patients compared with controls (p=0.03; or=13.5). conclusion: our results may suggest that possession of hla-drb1*01 increases the risk of ham/tsp in htlv-i-infected individuals and hla-cw*08 correlates with low ctl immune response in ham/tsp patients.
منابع مشابه
Association between HLA-DRB1*01 and HLA-Cw*08 and Outcome Following HTLV-I Infection
Background: Human T cell lymphotropic virus type I (HTLV-I)-associated myelopa-thy/tropical spastic paraparesis (HAM/TSP) is an inflammatory disease which occurs in less than 2% of HTLV-I -infected individuals. High proviral load, high HTLV-I-specific CD8+ cytotoxic T lymphocyte frequency (CTL) and host genetic factors such as HLA all appear to be associated with HTLV-I infection. Previous stud...
متن کاملAssociation between HLA-DRB1*01 and HLA-Cw*08 and outcome following HTLV-I infection.
BACKGROUND Human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory disease which occurs in less than 2% of HTLV-I -infected individuals. High proviral load, high HTLV-I-specific CD8+ cytotoxic T lymphocyte frequency (CTL) and host genetic factors such as HLA all appear to be associated with HTLV-I infection. Previous studie...
متن کاملAssociation between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City
Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system. We sought to investigate the association between HLA-class I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients.Methods: lymphocytes of 105 PT patients and 40 controls were phenotyped for H...
متن کاملAssociation between Hepatitis B Virus Infection Outcome and HLA-A and DRB1 Genotyping in North Part of Iran
Background and Objective: The outcome of hepatitis B virus (HBV) infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRB1 alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey in certain HLA ...
متن کاملAssociation between myasthenia gravis and HLA antigens in patients
Introduction: Myasthenia gravis is a disease of neuromuscular junction. Familial cases have been reported. Relation between myasthenia gravis and HLA antigens has been seen in many studies from different parts of the world. The aim of this study is determination of association between HLA class I haplotypes and myasthenia gravis in Kerman province. Methods: In this cross sectional study 44 my...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of immunologyجلد ۴، شماره ۲، صفحات ۹۴-۱۰۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023