tehranolide could shift the immune response towards th1 and modulate the intra-tumor infiltrated t regulatory cells
نویسندگان
چکیده
background: artemisia diffusa contains a new type of sesquiterpene lactone with an endoperoxide group (tehranolide). objective: due to the existing similarity between the structures of tehranolide and artemisinin, it was hypothesized that tehranolide would have similar effects as artemisinin. in this study, the immunotherapeutic effec-tiveness of tehranolide was investigated by direct intra-tumoral injection. methods: tehranolide was purified from artemisia diffusa, and its effect on the tumor volume was investigated. the splenocyte proliferation, shifting of cytokine profile, and the presence of naturally-occurring cd4+cd25+foxp3+ treg cells were assessed to describe the anti-tumor immune response. results: analysis of immune response showed that, intra-tumoral injection of tehranolide decreased the rate of tumor growth compared to control group. furthermore, the proliferative response of mice treated with tehranolide was en-hanced. in comparison with the control group, production of both il-4 and ifn-γ was in-duced (p
منابع مشابه
Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells
Background: Artemisia diffusa contains a new type of sesquiterpene lactone with an endoperoxide group (Tehranolide). Objective: Due to the existing similarity between the structures of Tehranolide and Artemisinin, it was hypothesized that Tehranolide would have similar effects as Artemisinin. In this study, the immunotherapeutic effec-tiveness of Tehranolide was investigated by direct intra-tum...
متن کاملTehranolide could shift the immune response towards Th1 and modulate the intra-tumor infiltrated T regulatory cells.
BACKGROUND Artemisia diffusa contains a new type of sesquiterpene lactone with an endoperoxide group (Tehranolide). OBJECTIVE Due to the existing similarity between the structures of Tehranolide and Artemisinin, it was hypothesized that Tehranolide would have similar effects as Artemisinin. In this study, the immunotherapeutic effectiveness of Tehranolide was investigated by direct intra-tumo...
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عنوان ژورنال:
iranian journal of immunologyجلد ۶، شماره ۴، صفحات ۲۱۶-۲۲۴
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