anti-cardiolipin and anti-neutrophil cytoplasmic antibodies in iranian patients with behcet's disease
نویسندگان
چکیده
background: the prevalence of anti-neutrophil cytoplasmic antibodies (ancas) and anti-cardiolipin antibodies (anti-cl ab) in behcet’s disease (bd) and also their roles in vascular involvement is controversial. objective: to assess the prevalence of ancas and anti-cl ab as well as their correlations with clinical manifestations in iranian patients with bd. methods: in this case/control study, the sera from 88 patients with bd and 88 healthy controls were evaluated. the levels of ancas and anti-cl ab were measured using indirect elisa method. results: the levels of anti-cl, anti-pr3 and anti-mpo (myeloperoxidase) igg autoantibodies between bd patients and healthy controls were not statistically different (p=0.21, p=0.28 and p=0.74, respectively). in addition, there were no significant deferences between bd patients with and without vascular involvement in the levels of anti-cl (1.42 ± 1.24 gplu/ml and 1.58 ± 1.18 gplu/ml, respectively; p=0.71), anti-pr3 (0.0 ± 0.0 u/ml and 0.08 ± 0.27 u/ml, respectively; p=0.10) and anti mpo (0.48 ± 0.23 u/ml and 0.52 ± 0.22 u/ml, respectively; p=0.41) igg autoantibodies. nevertheless, mean titer of anti-cl igg was higher in male patients with skin rash than those without skin rash (2.2 ± 0.88 gplu/ml and 1.11 ± 1.22 gplu/ml, respectively; p=0.017). conclusion: while anti-cl, anti- pr3 and anti-mpo igg autoantibodies do not play a major role in susceptibility to bd or pathogenesis of vascular involvement in our patients, anti-cl ab might be involved in skin lesion development in iranian male bd patients. however, the results should be confirmed in other studies.
منابع مشابه
Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Disease
Background: The prevalence of anti-Neutrophil Cytoplasmic Antibodies (ANCAs) and anti-Cardiolipin Antibodies (anti-CL Ab) in Behcet’s Disease (BD) and also their roles in vascular involvement is controversial. Objective: To assess the prevalence of ANCAs and anti-CL Ab as well as their correlations with clinical manifestations in Iranian patients with BD. Methods: In this case/control study, th...
متن کاملAnti-cardiolipin and anti-Neutrophil Cytoplasmic Antibodies in Iranian patients with Behcet's disease.
BACKGROUND The prevalence of anti-Neutrophil Cytoplasmic Antibodies (ANCAs) and anti-Cardiolipin Antibodies (anti-CL Ab) in Behcet's Disease (BD) and also their roles in vascular involvement is controversial. OBJECTIVE To assess the prevalence of ANCAs and anti-CL Ab as well as their correlations with clinical manifestations in Iranian patients with BD. METHODS In this case/control study, t...
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عنوان ژورنال:
iranian journal of immunologyجلد ۹، شماره ۴، صفحات ۲۴۱-۲۴۷
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