long acting propranolol and hsp-70 rich tumor lysate reduce tumor growth and enhance immune response against fibrosarcoma in balb/c mice
نویسندگان
چکیده
background: noradrenaline (na), the principal neurotransmitter released from sympathetic nerve terminals, influences t-cell maturation, not only directly in developing t cells, but also indirectly, by acting on the thymic nonlymphoid cells. in vitro and in vivo studies have demonstrated the anti-proliferative, anti-migratory, antiangiogenic and cytotoxic properties of propranolol, β-ar blocker, against various cancers. objectives: to evaluate the effect of propranolol on efficacy of hsp-70 rich lysate vaccine in immunotherapy of fibrosarcoma. methods: mouse fibrosarcoma wehi-164 cells were used to immunize tumor-bearing mice with or without propranolol and hsp-70. splenocytes proliferation, cytotoxic activity of the splenocytes, naturally occurring cd4+ cd25high t-reg cells and ifn-γ and il-4 secretion as well as tumor size, were assessed to describe the anti-tumor immune response. results: a significant increase in the level of ifn-γ in the mice vaccinated with wehi-164 cells enriched with hsp-70 and co-treated with propranolol was observed compared to controls. however, hsp enrichment or propranolol treatment alone did not enhance the immune response as measured by the level of ifn-γ. likewise, a decrease in tumor growth in the test group (p
منابع مشابه
Long Acting Propranolol and HSP-70 Rich Tumor Lysate Reduce Tumor Growth and Enhance Immune Response against Fibrosarcoma in Balb/c Mice
Background: Noradrenaline (NA), the principal neurotransmitter released from sympathetic nerve terminals, influences T-cell maturation, not only directly in developing T cells, but also indirectly, by acting on the thymic nonlymphoid cells. In vitro and in vivo studies have demonstrated the anti-proliferative, anti-migratory, antiangiogenic and cytotoxic properties of propranolol, β-AR blocker,...
متن کاملLong acting propranolol and HSP-70 rich tumor lysate reduce tumor growth and enhance immune response against fibrosarcoma in Balb/c mice.
BACKGROUND Noradrenaline (NA), the principal neurotransmitter released from sympathetic nerve terminals, influences T-cell maturation, not only directly in developing T cells, but also indirectly, by acting on the thymic nonlymphoid cells. In vitro and in vivo studies have demonstrated the anti-proliferative, anti-migratory, anti-angiogenic and cytotoxic properties of propranolol, β-AR blocker,...
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عنوان ژورنال:
iranian journal of immunologyجلد ۱۰، شماره ۲، صفحات ۷۰-۸۲
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