autoimmune hepatitis
نویسندگان
چکیده
background: â advanced hepatic fibrosis and cirrhosis has generally been considered to be irreversible. the aim of this study was to determine whether cirrhosis is reversible.â â methods: â seven patients with autoimmune hepatitis with histologic evidence of cirrhosis were enrolled. after treatment, they had follow-up liver biopsy while in clinical and biochemical remission. biopsy specimens were randomly coded in unpaired manner according to patient and were read independently by two pathologists using the modified hepatitis activity index (with a maximum stage of 6). results: three patients still had extensive fibrosis in the second liver biopsy. but four patients had almost total regression of their liver fibrosis. in the latter patients, the mean alanine aminotransferase level decreased from 776.3 u/l to 23 u/l. the mean bilirubin level decreased from 5.85 mg/dl, to 0.98 mg/dl. extensive fibrosis or cirrhosis were present in all patients at diagnosis but were not present on follow-up liver biopsy. the mean fibrosis score decreased from 5.88 to 0.5 (p=0.0002), and the mean grading score from 11.38 to 2.5 (p=0.0008). conclusion: frank cirrhosis due to autoimmune hepatitis may be reversible in some patients who respond to treatment.
منابع مشابه
Autoimmune hepatitis
Autoimmune hepatitis is (AIH) is a chronic hepatitis that occurs in children and adults of all ages. It is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. It was first described in the 1950s by term of chronic active hepatitis. It has 2 types with different auto antibodies. Diagnosis is based upon serologic and ...
متن کاملAutoimmune hepatitis.
N Engl J Med 2006;354:54-66. Copyright © 2006 Massachusetts Medical Society. A utoimmune hepatitis is a generally progressive, chronic hepatitis of unknown cause that occurs in children and adults of all ages. Occasionally, it has a fluctuating course, with periods of increased or decreased activity. The diagnosis is based on histologic abnormalities, characteristic clinical and biochemical fin...
متن کاملAutoimmune hepatitis.
Autoimmune hepatitis is an uncommon disease causing chronic inflammation of the liver and associated with various circulating autoantibodies. It shares some characteristics with other autoimmune liver diseases, such as primary biliary cirrhosis and sclerosing cholangitis. There has been confusion in past years regarding this entity, but there are now recognized diagnostic criteria by which to m...
متن کاملAutoimmune hepatitis.
Autoimmune hepatitis (AIH) is a rare disease, characterized by female predominance, hypergammaglobulinemia, autoantibodies, association with HLA DR3 and HLA DR4 and a good response to immunosuppression. Different subtypes of AIH may be distinguished, based on differences in the autoantibody patterns. AIH type 1 is characterized by anti-nuclear (ANA) and/or anti-smooth muscular (SMA) autoantibod...
متن کاملAutoimmune hepatitis
Recent advances Dominique-Charles VALLA The field of autoimmune hepatitis has been quite active since the last update on the topic at the Day of Hepatology of Beaujon Hospital in 2002. A simplified diagnostic score, better knowledge of some unusual forms, more solid criteria for remission and relapse, better understanding of prognostic factors, and especially improved therapeutic options are no...
متن کاملAutoimmune hepatitis.
Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased γ-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epi...
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گوارشجلد ۸، شماره ۳، صفحات ۶۷-۰
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