evaluation of interleukin-8 −251 t/a polymorphisms in visceral leishmaniasis
نویسندگان
چکیده
background: interleukin (il)-8 plays important roles in the recruitment and activation of immune cells during visceral leishmaniasis (vl). genetic variations in il-8 modulate the expression of il-8 protein and may be associated with vl. this study aimed to evaluate polymorphisms at the il-8 −251 position in vl patients. methods: this cross-sectional study was performed on three groups: leishmania -seropositive patients with clinical symptoms of vl (n = 91), seropositive patients without clinical symptoms (n = 104), and healthy controls (n = 110). polymorphisms at the il-8−251 position were analyzed using allele-specific polymerase chain reaction (pcr). anti- leishmania antibody titers were assessed by immunofluorescence. results: il -8 −251 polymorphism was significantly associated with vl ( p <0.002). the il-8−251 t/t genotype was significantly higher in group 1 than in groups 2 and 3 ( p <0.002). the validity of the data was analyzed using hardy-weinberg equilibrium and one-way analysis of variance (anova), as well as χ2 tests. conclusions: il-8−251 polymorphism was significantly associated with impaired immune responses in vl and might be considered a risk factor for disease development.
منابع مشابه
Evaluation of interleukin-8 -251 t/a polymorphisms in visceral leishmaniasis.
BACKGROUND Interleukin (IL)-8 plays important roles in the recruitment and activation of immune cells during visceral leishmaniasis (VL). Genetic variations in IL-8 modulate the expression of IL-8 protein and may be associated with VL. This study aimed to evaluate polymorphisms at the IL-8 -251 position in VL patients. METHODS This cross-sectional study was performed on three groups: Leishman...
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عنوان ژورنال:
journal of research in health sciencesجلد ۱۵، شماره ۱، صفحات ۵۹-۰
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