prognostic values of fluctuations in serum levels of alanine transaminase in inactive carrier state of hbv infection
نویسندگان
چکیده
conclusions fluctuations in serum alt levels may change the prognosis of a hbv inactive carrier state. objectives this study aimed to determine the incidence rate and patterns of alt fluctuations and prognostic values for the development of chronic hbv e antigen (hbeag)-negative hepatitis b (chb), hbv surface antigen (hbsag) seroclearance, and liver-related complications. patients and methods treatment-naïve patients with a chronic hbv infection, hbeag(-)/hbeab(+), normal alt levels, and hbv dna < 2000 iu/ml, were followed-up every 6-12 months by assessing serum alt levels. serum hbv dna was measured in cases of elevated alt levels. results a total of 399 patients were followed-up for 8.9 years; alt > upper limit of normal (uln, i.e. 40 iu/l) was detected in 103 (25.8%) patients, with an annual incidence rate of 2.9%. alt elevation was associated with; male gender, age, and higher serum alt levels at study entry. among the cases of alt elevations, 16 (15.5%) patients had alt levels > 2 × uln. there were 38 (36.9%) patients who had alt levels that remained > uln over six months, and 21 (20.4%) patients experienced at least two episodes of alt elevations. in 15 (14.6%) patients, elevated alt levels were associated with increased hbv replication (i.e. hbv dna > 2 000 iu/ml) and these were considered as chb. however, elevation of alt levels, even in the absence of hbv replication, increased the risk for the development of chb up to 8-fold in prospective follow-ups. hbsag seroclearance, cirrhosis, and hepatocellular carcinoma were detected in 43 (10.8%), 4 (1%), and 1 (0.25%) patients, respectively. background current guidelines introduce periodic monitoring of serum alanine transaminase (alt) as the first-line modality in follow-up patients, with a hepatitis b virus (hbv) inactive carrier state.
منابع مشابه
Prognostic Values of Fluctuations in Serum Levels of Alanine Transaminase in Inactive Carrier State of HBV Infection
BACKGROUND Current guidelines introduce periodic monitoring of serum alanine transaminase (ALT) as the first-line modality in follow-up patients, with a hepatitis B virus (HBV) inactive carrier state. OBJECTIVES This study aimed to determine the incidence rate and patterns of ALT fluctuations and prognostic values for the development of chronic HBV e antigen (HBeAg)-negative hepatitis B (CHB)...
متن کاملerratum to: prognostic values of fluctuations in serum levels of alanine transaminase in inactive carrier state of hbv infection [published in hepatitis monthly. 2014 may; 14(5): e17537]
متن کامل
Erratum to: Prognostic Values of Fluctuations in Serum Levels of Alanine Transaminase in Inactive Carrier State of HBV Infection [Published in Hepatitis Monthly. 2014 May; 14(5): e17537]
Copyright © 2014, Kowsar Corp.; Published by Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This erratum supplies corrected statements and proofs of an error made during publishing process. Hereby, Publi...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۴، شماره ۵، صفحات ۰-۰
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